Document Detail

Steroid metabolism in fish. II. Testosterone metabolites in the bile of the marine winter flounder Pseudopleuronectes americanus and the freshwater Atlantic Salmon Salmo salar.
MedLine Citation:
PMID:  6628972     Owner:  NLM     Status:  MEDLINE    
Intraarterial injection of [3H]testosterone in the flounder Pseudopleuronectes americanus and the landlocked salmon Salmo salar resulted in the concentration of radioactive catabolites in the gall bladder bile. The catabolites were quantitatively conjugated with glucuronic acid. In flounder bile, three steroids, testosterone, 5 beta-dihydrotestosterone and 5 beta-androstane-3 alpha,17 beta-diol accounted for most of the radioactivity. Quantitatively the concentration of 5 beta-dihydrotestosterone usually exceeded that of the other two compounds. In salmon bile, 5 alpha-dihydrotestosterone was also present as a minor catabolite and the dihydrotestosterones accounted for approximately one-half the total radioactivity. In both species there was evidence for trace amounts of 5 beta-androstane-3 beta,17 beta-diol, 5 alpha-androstane-3 alpha,17 beta-diol, and 5 alpha-androstane-3 beta,17 beta-diol but no evidence for 5 beta- or 5 alpha-androstanolones, 4-androstene-3 alpha,17 beta-diol, or its 3 beta-epimer. There were no obvious sex-related differences in the composition of the biliary testosterone metabolites.
B Truscott
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  General and comparative endocrinology     Volume:  51     ISSN:  0016-6480     ISO Abbreviation:  Gen. Comp. Endocrinol.     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1983-12-17     Completed Date:  1983-12-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370735     Medline TA:  Gen Comp Endocrinol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  460-70     Citation Subset:  IM    
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MeSH Terms
Androstane-3,17-diol / metabolism
Bile / metabolism*
Dihydrotestosterone / metabolism
Fishes / metabolism*
Salmon / metabolism*
Testosterone / metabolism*
Reg. No./Substance:
25126-76-5/Androstane-3,17-diol; 521-18-6/Dihydrotestosterone; 58-22-0/Testosterone

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