Document Detail


Steroid hormone control of myometrial contractility and parturition.
MedLine Citation:
PMID:  17613262     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The precise temporal control of uterine contractility is essential for the success of pregnancy. For most of pregnancy, progesterone acting through genomic and non-genomic mechanisms promotes myometrial relaxation. At parturition the relaxatory actions of progesterone are nullified and the combined stimulatory actions of estrogens and other factors such as myometrial distention and immune/inflammatory cytokines, transform the myometrium to a highly contractile and excitable state leading to labor and delivery. This review addresses current understanding of how progesterone and estrogens affect the contractility of the pregnancy myometrium and how their actions are coordinated and controlled as part of the parturition cascade.
Authors:
Sam Mesiano; Toni N Welsh
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2007-05-18
Journal Detail:
Title:  Seminars in cell & developmental biology     Volume:  18     ISSN:  1084-9521     ISO Abbreviation:  Semin. Cell Dev. Biol.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-08-13     Completed Date:  2007-11-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9607332     Medline TA:  Semin Cell Dev Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  321-31     Citation Subset:  IM    
Affiliation:
Department of Reproductive Biology, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106-5034, United States. sam.mesiano@case.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Estrogens / metabolism*
Female
Gene Expression
Humans
Myometrium / physiology*
Parturition*
Progesterone / metabolism*
Receptors, Progesterone / metabolism
Uterine Contraction*
Grant Support
ID/Acronym/Agency:
HD051563/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Estrogens; 0/Receptors, Progesterone; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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