Document Detail


Stereotaxic irradiation of brain tumors.
MedLine Citation:
PMID:  2154318     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Stereotaxic techniques may be used in combination with interstitial or external beam radiotherapy for the treatment of intracranial malignancies. At the University of California, San Francisco, temporary, high-activity, iodine 125 sources are used mainly for the treatment of malignant gliomas. Patients with unifocal lesions that are smaller than 5 to 6 cm have discrete margins on computed tomography (CT) limited to supratentorial regions are selected for stereotaxic implantation. Both primary and recurrent malignant gliomas are treated with stereotaxic implantation; primary malignant gliomas are treated in addition with nonstereotaxic external beam radiotherapy and concomitant and sequential chemotherapy. Median survival times measured from the time of implantation are as follows: primary glioblastoma multiforme, 95 weeks; recurrent glioblastoma multiforme, 54 weeks; primary anaplastic astrocytoma, 223 weeks; and recurrent anaplastic astrocytoma, 81 weeks. Stereotaxic interstitial brachytherapy in conjunction with hyperthermia (thermoradiotherapy) is being studied in the treatment of recurrent or metastatic intracranial malignancy. External beam radiotherapy delivered stereotaxically in a single fraction (radiosurgery) has been used mainly for benign intracranial processes, although several centers are now exploring its use in the management of highly selected malignant lesions. Although its role is not yet completely defined, it may prove useful in highly selected subsets of patients with small intracranial malignancies, whether primary, recurrent, or metastatic.
Authors:
D A Larson; P H Gutin; S A Leibel; T L Phillips; P K Sneed; W M Wara
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Cancer     Volume:  65     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-03-19     Completed Date:  1990-03-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  792-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Radiation Oncology, University of California, San Francisco 94153.
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MeSH Terms
Descriptor/Qualifier:
Animals
Astrocytoma / radiotherapy
Brachytherapy / methods*
Brain Neoplasms / radiography,  radiotherapy*,  secondary
Combined Modality Therapy
Craniotomy
Glioblastoma / radiotherapy
Glioma / radiotherapy
Humans
Hyperthermia, Induced
Iodine Radioisotopes / therapeutic use
Magnetic Resonance Imaging
Neoplasm Recurrence, Local / radiotherapy
Stereotaxic Techniques* / adverse effects
Tomography, X-Ray Computed
Grant Support
ID/Acronym/Agency:
CA13525/CA/NCI NIH HHS; CA19408/CA/NCI NIH HHS; CA21439/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Iodine Radioisotopes

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