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Stereotactic radiotherapy of histologically proven inoperable stage I non-small cell lung cancer: Patterns of failure.
MedLine Citation:
PMID:  21724287     Owner:  NLM     Status:  Publisher    
BACKGROUND AND PURPOSE: To report patterns of failure of stereotactic body radiation therapy (SBRT) in inoperable patients with histologically confirmed stage I NSCLC. MATERIALS AND METHODS: Ninety-two inoperable patients (median age: 75years) with clinically staged, histologically proven T1 (n=31) or T2 (n=61), N0, M0 non-small cell lung cancer (NSCLC) were included in this study. Treatment consisted of 3-5 fractions with 7-15Gy per fraction prescribed to the 60% isodose. RESULTS: Freedom from local recurrence at 1, 3 and 5years was 89%, 83% and 83%, respectively. All 10 local failures were observed in patients with T2 tumors. Isolated regional recurrence was observed in 7.6%. The crude rate of distant progression was 20.7%. Overall survival at 1, 3, and 5years was 79%, 38% and 17% with a median survival of 29months. Disease specific survival at 1, 3, and 5years was 93%, 64% and 48%. Karnofsky performance status, T stage, gross tumor volume and tumor location had no significant impact on overall and disease specific survival. SBRT was generally well tolerated and all patients completed therapy as planned. CONCLUSION: SBRT for stage I lung cancer is very well tolerated in this patient cohort with significant cardiopulmonal comorbidity and results in excellent local control rates, although a considerable portion develops regional and distant metastases.
Nicolaus Andratschke; Frank Zimmermann; Eva Boehm; Sabine Schill; Christine Schoenknecht; Reinhard Thamm; Michael Molls; Carsten Nieder; Hans Geinitz
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-1
Journal Detail:
Title:  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology     Volume:  -     ISSN:  1879-0887     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8407192     Medline TA:  Radiother Oncol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Department of Radiotherapy and Radiation Oncology, Technische Universität München, Germany.
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