Document Detail


Stereotactic radiosurgery for intracranial arteriovenous malformations using a standard linear accelerator.
MedLine Citation:
PMID:  2674079     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have previously described the development of a technique which utilizes a standard linear accelerator to provide stereotactic, limited field radiation. The radiation is delivered using a modified and carefully calibrated 6 MV linear accelerator. Precise target localization and patient immobilization is achieved using a Brown-Roberts-Wells (BRW) stereotactic head frame which is in place during angiography, CT scanning, and treatment. Seventeen arteriovenous malformations (AVMs) have been treated in 16 patients from February 1986 to July 1988. Single doses of 1500-2500 cGy were delivered using multiple non-coplanar arcs with small, sharp edged x-ray beams to lesions less than 2.7 cm in greatest diameter. The dose distribution from this technique has a very rapid dropoff of dose beyond the target volume. Doses were prescribed at the periphery of the AVMs, typically to the 80-90% isodose line. Eleven of 16 patients have been followed by repeat angiography at least 1 year following treatment. Five of 11 have had complete obliteration of their AVM in 1 year and an additional three patients have achieved complete obliteration by 24 months. There have been no incidences of rebleeding or serious complications in any patient. We conclude that stereotactic radiosurgery using a standard linear accelerator is an effective and safe technique in the treatment of intracranial AVMs and the results compare favorably to the more expensive and elaborate systems that are currently available for stereotactic treatments.
Authors:
J S Loeffler; E Alexander; R L Siddon; W M Saunders; C N Coleman; K R Winston
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of radiation oncology, biology, physics     Volume:  17     ISSN:  0360-3016     ISO Abbreviation:  Int. J. Radiat. Oncol. Biol. Phys.     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1989-10-13     Completed Date:  1989-10-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7603616     Medline TA:  Int J Radiat Oncol Biol Phys     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  673-7     Citation Subset:  IM    
Affiliation:
Department of Radiation Therapy, Harvard Medical School, Boston, MA 02115.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Child
Child, Preschool
Humans
Intracranial Arteriovenous Malformations / radiotherapy*
Middle Aged
Particle Accelerators*
Stereotaxic Techniques*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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