Document Detail

Stereotactic radiosurgery of cerebral arteriovenous malformations: appearance of perinidal T(2) hyperintensity signal as a predictor of favorable treatment response.
MedLine Citation:
PMID:  10853098     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to analyze the significance of perinidal T(2) hyperintensity appearance after radiosurgery of arteriovenous malformations (AVMs), as a predictor of treatment response. Our initial experience with linear accelerator (LINAC) radiosurgery at University of California, Los Angeles, between 1990 and 1997 involved treatment of 129 patients affected by cerebral AVMs. Based upon availability of neuroimaging follow-up, 48 patients with 50 AVMs were selected for review. Forty (80%) of the AVMs underwent complete obliteration or significant reduction on follow-up MRI, on average 20 months after radiosurgery. Thirteen (72%) of 18 obliterated AVMs were associated with perinidal T(2) hyperintensity signal, on average 18 months (6-49) after radiosurgery. Ten (20%) of 50 AVMs (average volume 23.1 cm(3), ranging 7.5-46.5) were unchanged. Furthermore, only 3 AVMs in this group showed reversible T(2) signal changes. In patients with complete nidal obliteration, appearance of T(2) hyperintensity signal achieves 72% sensitivity in predicting successful treatment response.
F Mobin; A A De Salles; O Abdelaziz; C Cabatan-Awang; T Solberg; M Selch
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Stereotactic and functional neurosurgery     Volume:  73     ISSN:  1011-6125     ISO Abbreviation:  Stereotact Funct Neurosurg     Publication Date:  1999  
Date Detail:
Created Date:  2000-09-14     Completed Date:  2000-09-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8902881     Medline TA:  Stereotact Funct Neurosurg     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  50-9     Citation Subset:  IM    
Copyright Information:
Copyright 2000 S. Karger AG, Basel
Department of Neurosurgery and Radiation Oncology, School of Medicine, University of California, Los Angeles, USA.
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MeSH Terms
Follow-Up Studies
Intracranial Arteriovenous Malformations / diagnosis*,  surgery*
Magnetic Resonance Imaging*
Middle Aged
Sensitivity and Specificity
Stereotaxic Techniques*
Treatment Outcome

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