| Stereotactic helium ion Bragg peak radiosurgery for intracranial arteriovenous malformations. Detailed clinical and neuroradiologic outcome. | |
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MedLine Citation:
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PMID: 1808653 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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89 patients with angiographically documented arteriovenous malformations were treated with helium ion Bragg peak radiation. The rate of complete angiographic obliteration 2 years after radiation was 94% in those lesions smaller than 4 cm3 (2.0 cm in diameter), 75% for those 4-25 cm3 and 39% for those larger than 25 cm3 (3.7 cm in diameter); at 3 years after radiation, the corresponding obliteration rates were 100, 95 and 70%. Major clinical complications occurred in 10 patients (8 permanent, 2 transient) between 3 and 21 months after treatment; all were in the initial stage of the protocol (higher radiation doses). 10 patients bled from residual malformation between 4 and 34 months after treatment. Seizures were improved in 63% and headaches in 68% of patients. Excellent or good clinical outcome was achieved in 94% of patients. Compared to the natural history and risks of surgery for these difficult malformations, we consider these results encouraging. Heavy-charged-particle radiation is a valuable therapy for surgically inaccessible symptomatic cerebral arteriovenous malformations. The current procedure has two disadvantages: the prolonged latent period before complete obliteration and the small risk of serious neurological complications. |
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Authors:
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G K Steinberg; J I Fabrikant; M P Marks; R P Levy; K A Frankel; M H Phillips; L M Shuer; G D Silverberg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Stereotactic and functional neurosurgery Volume: 57 ISSN: 1011-6125 ISO Abbreviation: Stereotact Funct Neurosurg Publication Date: 1991 |
Date Detail:
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Created Date: 1992-05-21 Completed Date: 1992-05-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8902881 Medline TA: Stereotact Funct Neurosurg Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 36-49 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Stanford University School of Medicine, Calif. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Brain / pathology, radiography Cerebral Angiography Cerebral Hemorrhage / etiology Child Female Helium Humans Intracranial Arteriovenous Malformations / diagnosis, surgery* Ions Magnetic Resonance Imaging Male Middle Aged Postoperative Complications Radiosurgery* / adverse effects Stereotaxic Techniques* Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Ions; 7440-59-7/Helium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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