Document Detail

Stereotactic helium ion Bragg peak radiosurgery for intracranial arteriovenous malformations. Detailed clinical and neuroradiologic outcome.
MedLine Citation:
PMID:  1808653     Owner:  NLM     Status:  MEDLINE    
89 patients with angiographically documented arteriovenous malformations were treated with helium ion Bragg peak radiation. The rate of complete angiographic obliteration 2 years after radiation was 94% in those lesions smaller than 4 cm3 (2.0 cm in diameter), 75% for those 4-25 cm3 and 39% for those larger than 25 cm3 (3.7 cm in diameter); at 3 years after radiation, the corresponding obliteration rates were 100, 95 and 70%. Major clinical complications occurred in 10 patients (8 permanent, 2 transient) between 3 and 21 months after treatment; all were in the initial stage of the protocol (higher radiation doses). 10 patients bled from residual malformation between 4 and 34 months after treatment. Seizures were improved in 63% and headaches in 68% of patients. Excellent or good clinical outcome was achieved in 94% of patients. Compared to the natural history and risks of surgery for these difficult malformations, we consider these results encouraging. Heavy-charged-particle radiation is a valuable therapy for surgically inaccessible symptomatic cerebral arteriovenous malformations. The current procedure has two disadvantages: the prolonged latent period before complete obliteration and the small risk of serious neurological complications.
G K Steinberg; J I Fabrikant; M P Marks; R P Levy; K A Frankel; M H Phillips; L M Shuer; G D Silverberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Stereotactic and functional neurosurgery     Volume:  57     ISSN:  1011-6125     ISO Abbreviation:  Stereotact Funct Neurosurg     Publication Date:  1991  
Date Detail:
Created Date:  1992-05-21     Completed Date:  1992-05-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8902881     Medline TA:  Stereotact Funct Neurosurg     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  36-49     Citation Subset:  IM    
Department of Neurosurgery, Stanford University School of Medicine, Calif.
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MeSH Terms
Brain / pathology,  radiography
Cerebral Angiography
Cerebral Hemorrhage / etiology
Intracranial Arteriovenous Malformations / diagnosis,  surgery*
Magnetic Resonance Imaging
Middle Aged
Postoperative Complications
Radiosurgery* / adverse effects
Stereotaxic Techniques*
Tomography, X-Ray Computed
Reg. No./Substance:
0/Ions; 7440-59-7/Helium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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