Document Detail


Stereospecific reduction of 3- and 7-oxo groups of oxocholanic acids in isolated perfused rat liver.
MedLine Citation:
PMID:  7129365     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The metabolism of 3- and 7-oxo groups of oxocholanic acids was studied in isolated perfused rat liver. The metabolites in bile were determined enzymatically using 3 alpha- and 7 alpha-hydroxysteroid dehydrogenases. The 3-oxo group of all the oxocholanic acids tested (dehydrocholate, glycodehydrocholate, taurodehydrocholate, 3,7-dioxocholanate, 3,12-dioxocholanate and tauro-7,12-dihydroxy-3-oxocholanate) was reduced stereospecifically to 3 alpha-hydroxy metabolites. On the other hand the 7-oxo group was excreted partially unchanged (30% of the dose) and partially as 7 alpha-hydroxy metabolites (6-10% of the dose). The remainder of the 7-oxo group was concluded to have been reduced to 7 beta-hydroxy metabolites. These results indicate that the 7-oxo group of oxocholanic acids is reduced predominantly to 7 beta-hydroxy metabolites in rats rather than to 7 alpha-hydroxy metabolites as found in man.
Authors:
M S Anwer; D Hegner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hoppe-Seyler's Zeitschrift für physiologische Chemie     Volume:  363     ISSN:  0018-4888     ISO Abbreviation:  Hoppe-Seyler's Z. Physiol. Chem.     Publication Date:  1982 Jul 
Date Detail:
Created Date:  1982-12-21     Completed Date:  1982-12-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985060R     Medline TA:  Hoppe Seylers Z Physiol Chem     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  731-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Bile / metabolism
Cholic Acids / metabolism*
Deoxycholic Acid / analogs & derivatives,  metabolism
Liver / metabolism*
Male
Perfusion
Rats
Rats, Inbred Strains
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Cholic Acids; 83-44-3/Deoxycholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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