Document Detail

Stereospecific lactate absorption during peritoneal dialysis.
MedLine Citation:
PMID:  7121668     Owner:  NLM     Status:  MEDLINE    
Patients undergoing peritoneal dialysis were studied to determine if peritoneal absorption was selective. Dialysis was performed using dialysate exchange schedules similar to those for intermittent peritoneal dialysis and continuous ambulatory peritoneal dialysis. The clearance rate from the peritoneal cavity during hourly dialysate exchanges was 6.2 ml/min for D (-)-lactate and 8.7 ml/min for L(+)-lactate (p less than 0.01). L(+)-Lactate disappeared more rapidly from the dialysate during the long-cycle exchanges. Our results suggest that clearance of lactate from the peritoneal cavity is relatively stereospecific and raises the question of selective absorption for other organic anions.
J Rubin; C Adair; B Johnson; J D Bower
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nephron     Volume:  31     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1982  
Date Detail:
Created Date:  1982-12-02     Completed Date:  1982-12-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  224-8     Citation Subset:  IM    
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MeSH Terms
Citrates / metabolism*
Citric Acid
Glomerulonephritis / therapy
Hydrogen-Ion Concentration
Hypertension, Renal / therapy
Middle Aged
Molecular Conformation
Peritoneal Cavity
Peritoneal Dialysis*
Peritoneal Dialysis, Continuous Ambulatory
Reg. No./Substance:
0/Citrates; 77-92-9/Citric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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