Document Detail

Stereospecific feeding modulation by endogenous organic acid gamma-lactone in rats.
MedLine Citation:
PMID:  2644849     Owner:  NLM     Status:  MEDLINE    
Stereospecificity of 3,4-dihydroxybutanoic acid gamma-lactone (3,4-DB) and 2,4,5-trihydroxypentanoic acid gamma-lactone (2,4,5-TP) in their effects on feeding behavior and humoral factors was assessed by infusion into the rat third cerebroventricle. Initial transient food intake was most potently affected by infusion of 2.50 mumol of the 2S,4S-stereoisomer of 2,4,5-TP (80%) at 1100 h. Among the others, 2.50 mumol of the 2R,4S-isomer was somewhat potent in feeding elicitation (20%). Feeding induced by these isomers was not accompanied by periprandial drinking. Ambulation increased with elicitation of feeding. During the first dark period after infusion at 1940 h, 2.50 mumol of the 3S-isomer of 3,4-DB decreased food intake, including reduced meal size, and prolonged postprandial intermeal interval, but the 3R-isomer did not. Potent hypoglycemia with hyperinsulinemia was caused by the 2S,4S-isomer of 2,4,5-TP, and the S-isomer of 3,4-DB caused responses that were reciprocal to those to 2,4,5-TP. The remaining isomers did not affect feeding or humoral factors. The results suggest that the S- or S,S-stereo-isomer of the endogenous organic acid gamma-lactones may be important in modulating food intake through the hypothalamus.
T Sakata; K Terada; K Arase; K Fujimoto; Y Oomura; N Okukado; O Uchikawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  256     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-03-23     Completed Date:  1989-03-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R366-70     Citation Subset:  IM    
Department of Internal Medicine I, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
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MeSH Terms
4-Butyrolactone / analogs & derivatives,  pharmacology*
Appetite Depressants / pharmacology*
Blood Glucose / metabolism
Drinking Behavior / drug effects
Feeding Behavior / drug effects*
Furans / pharmacology*
Insulin / blood
Motor Activity / drug effects
Rats, Inbred Strains
Reference Values
Sugar Acids / pharmacology*
Reg. No./Substance:
0/Appetite Depressants; 0/Blood Glucose; 0/Furans; 0/Sugar Acids; 11061-68-0/Insulin; 34371-14-7/2,4,5-trihydroxypentanoic acid gamma-lactone; 5469-16-9/3,4-dihydroxybutanoic acid gamma-lactone; 96-48-0/4-Butyrolactone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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