| Stereoselective excretion of (3-methoxy-4-sulphooxyphenyl)ethylene glycol (MHPG sulphate) in the dog. | |
| | |
MedLine Citation:
|
PMID: 7442827 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
3-Methoxy-4-hydroxyphenylethylene glycol (MHPG) labelled with six deuterium atoms ([2H6]MHPG) was infused into two female greyhound dogs. Plasma and urine were analyzed for endogenous MHPG and [2H6]MHPG and their conjugates by the technique of selected ion monitoring gas chromatography-mass spectrometry. This analysis showed that the major forms of MHPG and [2H6]MHPG in the plasma and urine of the greyhounds were the sulphate conjugates. However, the plasma concentration of [2H6]MHPG sulphate increased continuously during the infusion period and the renal clearance of this compound was found to be much less than that of the endogenous sulphate. The explanation that his was due either to saturation of a renal transport mechanism or to a deuterium isotope effect was eliminated. Stereochemical analysis showed that, while the [2H6]MHPG used for infusion was a racemic mixture of two stereoisomers, much more of the nature(-)stereoisomer of [2H6]MHPG sulphate was excreted in the dog urine. It was also shown that both the (+) and (-)stereoisomers of [2H6]MHPG sulphate were sulphoconjugated at the 4-position of the aromatic ring. |
| | |
Authors:
|
S Murray; A R Boobis; H Frank; T A Baillie; D S Davies |
Related Documents
:
|
6307087 - A possible central opiate mechanism involved in the inhibition of food intake and retic... 3963237 - Glucagon-induced inhibition of feeding is impaired by hepatic portal alloxan injection. 8399117 - The role of propionate and acetate in the control of food intake in sheep. 9460227 - Induction and inhibition of cytochrome p450 isoforms by imazalil, a food contaminant, i... 23197837 - Developing a broader scientific foundation for river restoration: columbia river food w... 14506887 - Can human micronutrient status be improved by supplementing domestic animals? |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Naunyn-Schmiedeberg's archives of pharmacology Volume: 314 ISSN: 0028-1298 ISO Abbreviation: Naunyn Schmiedebergs Arch. Pharmacol. Publication Date: 1980 Oct |
Date Detail:
|
Created Date: 1981-02-26 Completed Date: 1981-02-26 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0326264 Medline TA: Naunyn Schmiedebergs Arch Pharmacol Country: GERMANY, WEST |
Other Details:
|
Languages: eng Pagination: 89-96 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Biotransformation Creatinine / urine Dogs Female Glucuronates / blood Glycols / urine* Methoxyhydroxyphenylglycol / urine* Protein Binding Stereoisomerism |
| Chemical | |
Reg. No./Substance:
|
0/Glucuronates; 0/Glycols; 534-82-7/Methoxyhydroxyphenylglycol; 60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Requirement for sulfhydryl groups in the differential effects of magnesium ion and GTP on agonist bi...
Next Document: Effect of diazepam on cyclic changes in excitability in cortical epileptic foci