Document Detail

Stereoselective actions of S-nitrosocysteine in central nervous system of conscious rats.
MedLine Citation:
PMID:  9176306     Owner:  NLM     Status:  MEDLINE    
This study examined whether the stereoselective actions of S-nitrosocysteine (SNC) in the central nervous system involves the activation of stereoselective SNC recognition sites. We examined the effects produced by intracerebroventricular injection of the L- and D-isomers of SNC (L- and D-SNC) on mean arterial blood pressure, heart rate, and vascular resistances in conscious rats. We also examined the hemodynamic effects produced by intracerebroventricular injections of 1) L-cystine, the major non-nitric oxide (NO) decomposition product of L-SNC, 2) the parent thiols L- and D-cysteine, and 3) the bulky S-nitrosothiol L-S-nitroso-gamma-glutamylcysteinylglycine [L-S-nitrosoglutathione, (L-SNOG)]. Finally, we examined the decomposition of L- and D-SNC and L-SNOG to NO on their addition to brain homogenates. The intracerebroventricular injection of L-SNC (250-1,000 nmol) produced falls in mean arterial pressure, increases in heart rate, and a dose-dependent pattern of changes in hindquarter, renal, and mesenteric vascular resistances. The intracerebroventricular injections of D-SNC, L-cystine, and L-SNOG produced only minor effects. The intracerebroventricular injection of L-cysteine produced pressor responses and tachycardia, whereas D-cysteine was inactive. L- and D-SNC decomposed equally to NO on addition to brain homogenates. L-SNOG decomposed to similar amounts of NO as L- and D-SNC. These results suggest that SNC may activate stereoselective SNC recognition sites on brain neurons and that S-nitrosothiols of substantially different structure do not stimulate these sites. These recognition sites may be stereoselective membrane-bound receptors for which L-SNC is the unique ligand.
R L Davisson; M D Travis; J N Bates; A K Johnson; S J Lewis
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  272     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-06-27     Completed Date:  1997-06-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H2361-8     Citation Subset:  IM; S    
Cardiovascular Center, University of Iowa, Iowa City 52242, USA.
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MeSH Terms
Blood Pressure / drug effects
Central Nervous System / drug effects*
Cysteine / analogs & derivatives*,  pharmacology
Cystine / pharmacology
Dose-Response Relationship, Drug
Glutathione / analogs & derivatives,  pharmacology
Heart Rate / drug effects
Hemodynamics / drug effects
Injections, Intraventricular
Nitric Oxide / metabolism
Nitroso Compounds / pharmacology
Rats, Sprague-Dawley
Grant Support
Reg. No./Substance:
0/Nitroso Compounds; 0/S-Nitrosothiols; 10102-43-9/Nitric Oxide; 51209-75-7/S-nitrosocysteine; 52-90-4/Cysteine; 56-89-3/Cystine; 57564-91-7/S-Nitrosoglutathione; 70-18-8/Glutathione

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