Document Detail


Stereoselective and chiroselective surface plasmon resonance (SPR) analysis of amino acids by molecularly imprinted Au-nanoparticle composites.
MedLine Citation:
PMID:  20533386     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Au nanoparticles (NPs) functionalized with thioaniline and cysteine are used to assemble bis-aniline-bridged Au-NP composites on Au surfaces using an electropolymerization process. During the polymerization of the functionalized Au NPs in the presence of different amino acids, for example, L-glutamic acid, L-aspartic acid, L-histidine, and L-phenylalanine, zwitterionic interactions between the amino acids and the cysteine units linked to the particles lead to the formation of molecularly imprinted sites in the electropolymerized Au-NP composites. Following the elimination of the template amino acid molecules, the electropolymerized matrices reveal selective recognition and binding capabilities toward the imprinted amino acid. Furthermore, by imprinting of L-glutamic or D-glutamic acids, chiroselective imprinted sites are generated in the Au-NP composites. The binding of amino acids to the imprinted recognition sites was followed by surface plasmon resonance spectroscopy. The refractive index changes occurring upon the binding of the amino acids to the imprinted sites are amplified by the coupling between the localized plasmon associated with the Au NPs and the surface plasmon wave.
Authors:
Michael Riskin; Ran Tel-Vered; Marco Frasconi; Nimrod Yavo; Itamar Willner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chemistry (Weinheim an der Bergstrasse, Germany)     Volume:  16     ISSN:  1521-3765     ISO Abbreviation:  Chemistry     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-28     Completed Date:  2010-09-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9513783     Medline TA:  Chemistry     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  7114-20     Citation Subset:  IM    
Affiliation:
Institute of Chemistry, Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / chemistry*
Binding Sites
Gold / chemistry*
Molecular Imprinting / methods
Molecular Structure
Nanoparticles / chemistry*
Stereoisomerism
Surface Plasmon Resonance / methods
Chemical
Reg. No./Substance:
0/Amino Acids; 7440-57-5/Gold

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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