Document Detail

Stereological study of the effect of altitude on the trophoblast cell populations of human term placental villi.
MedLine Citation:
PMID:  9250708     Owner:  NLM     Status:  MEDLINE    
Paraffin-embedded histological material was examined from 10 placentae from uncomplicated pregnancies at high altitude (3000 m). This was compared with material from 10 placentae delivered at low altitude (500 m). The sample groups were matched for maternal age, gestational age and parity. Within terminal and intermediate villi the volume-weighted mean cytotrophoblast cell volume did not significantly change at high altitude (754.1 microm3 at low altitude versus 796 microm3 at high altitude). The fractional volume of the villi occupied by cytotrophoblastic cells and their nuclei number per 10000 microm3 of villous tissue were significantly greater in placenta from high altitude (3.17 and 1.86 per cent, respectively) than those from low altitude (1.05 and 0.79 per cent, respectively) (P<0.0004 and P<0.0058, respectively). No significant differences in either fractional volume of the syncytiotrophoblast or its nuclei number per 10000 microm3 of villous tissue were observed between placentae from high (26.01 and 11.6 per cent, respectively) and low altitude (26.33 and 11.89 per cent, respectively). These results suggest an increase in the number of cytotrophoblastic cells at high altitudes without any changes in their volume. Exposure to hypobaric hypoxia is thought to be the principal aetiological factor.
K Z Ali
Related Documents :
8926248 - Augmented hypoxic cerebral vasodilation in men during 5 days at 3,810 m altitude.
11740628 - Historical and geological evidence for seismic origin of newly recognized landslides in...
23130108 - Cardiopulmonary exercise testing reveals onset of disease and response to treatment in ...
19520908 - Dexamethasone but not tadalafil improves exercise capacity in adults prone to high-alti...
2857088 - Are the clinical benefits of oral prenalterol in ischaemic heart failure due to beta bl...
22465868 - The effects of acute exercise bouts on hepcidin in women.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Placenta     Volume:  18     ISSN:  0143-4004     ISO Abbreviation:  Placenta     Publication Date:    1997 Jul-Aug
Date Detail:
Created Date:  1997-09-25     Completed Date:  1997-09-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  447-50     Citation Subset:  IM    
Anatomy Department, College of Medicine, King Saud University, Abha Branch, Saudi Arabia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cell Count
Cell Nucleus / ultrastructure
Cell Size
Chorionic Villi / ultrastructure*
Trophoblasts / ultrastructure*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Constitutive and induced cytokine production by human placenta and amniotic membrane at term.
Next Document:  Influence of hypoxia on vascular endothelial growth factor and chorionic gonadotrophin production in...