Document Detail

Stereological and functional investigations on isolated adrenocortical cells. I. Adrenocortical cells of normal adult rats.
MedLine Citation:
PMID:  2546665     Owner:  NLM     Status:  MEDLINE    
The function and morphology of isolated rat adrenocortical cells were investigated. Capsular (zona glomerulosa) cells secreted aldosterone, progesterone and small amounts of corticosterone; inner (zonae fasciculata and reticularis) cells produced corticosterone and progesterone. ACTH (10(-8) M) exposure caused a striking rise in aldosterone and corticosterone secretion by capsular cells, and in corticosterone release by inner cell preparations; simultaneously, progesterone secretion was significantly reduced. Capsular and inner cells possessed an average volume of 500 and 1250 micron 3, and ultrastructural qualitative and quantitative (stereological) features closely resembling those of zona glomerulosa and zona fasciculata-reticularis cells in situ, respectively. ACTH exposure caused a notable lipid-droplet depletion in both types of isolated cells.
P G Andreis; G Neri; L Cavallini; P Rebuffat; G Mazzocchi; G G Nussdorfer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of submicroscopic cytology and pathology     Volume:  21     ISSN:  1122-9497     ISO Abbreviation:  J. Submicrosc. Cytol. Pathol.     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-09-01     Completed Date:  1989-09-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8804312     Medline TA:  J Submicrosc Cytol Pathol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  357-65     Citation Subset:  IM    
Department of Anatomy, University of Padua, Italy.
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MeSH Terms
Adrenal Cortex / cytology*,  physiology,  secretion
Aldosterone / secretion
Cell Separation
Corticosterone / secretion
Deoxyribonucleases / diagnostic use
Microbial Collagenase / diagnostic use
Progesterone / secretion
Rats, Inbred Strains
Reg. No./Substance:
50-22-6/Corticosterone; 52-39-1/Aldosterone; 57-83-0/Progesterone; EC 3.1.-/Deoxyribonucleases; EC Collagenase

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