Document Detail


Stereological estimates of nuclear number in human ventricular cardiomyocytes before and after birth obtained using physical disectors.
MedLine Citation:
PMID:  9279664     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Design-based stereology is employed to estimate total numbers of myocyte nuclei and mean myocyte volume per nucleus in ventricles of fetal and early postnatal human hearts. Organs were collected postmortem from subjects varying in age from 16 gestational wk to 40 postnatal wk. Numbers of myocyte nuclei per unit volume of ventricle were estimated using physical disectors (parallel pairs of sections). Absolute numbers were calculated by multiplying nuclear packing densities by ventricular volumes estimated from ventricular mass and tissue density. Volumes per nucleus were obtained via estimates of the combined volumes of all myocytes (or of the myocardium as a whole) and the numbers of myocyte nuclei. The findings showed that numbers of myocyte nuclei increase linearly from 16 wk towards term. They were also consistent with the notion that hyperplasia ceases abruptly at birth or soon afterwards. The net rate of production of myocyte nuclei was about 38 x 10(7)/wk (2.3 million nuclei/h). The total volume of myocytes continued to expand in the same way from 16 wk to at least 35 wk of gestation. Published studies on the incidence of binucleate myocytes during early postnatal growth of the ventricles of rats suggest that the volume of a myocyte doubles prior to nuclear division. Prenatal growth in the human heart is consistent with this mechanism. Myocardial hypertrophy after birth must occur by cellular hypertrophy without karyokinesis.
Authors:
T M Mayhew; A Pharaoh; A Austin; D G Fagan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of anatomy     Volume:  191 ( Pt 1)     ISSN:  0021-8782     ISO Abbreviation:  J. Anat.     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-09-18     Completed Date:  1997-09-18     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0137162     Medline TA:  J Anat     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  107-15     Citation Subset:  IM    
Affiliation:
Department of Human Anatomy & Cell Biology, Queen's Medical Centre, Nottingham, UK.
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MeSH Terms
Descriptor/Qualifier:
Cell Nucleus / ultrastructure*
Fetal Heart / ultrastructure*
Gestational Age
Humans
Hyperplasia
Hypertrophy
Infant
Infant, Newborn
Myocardium / ultrastructure*
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