Document Detail


Stereological changes in the capillary network of the aging dorsal lateral geniculate nucleus.
MedLine Citation:
PMID:  12923896     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this work we studied the effect of aging on the capillaries of the dorsal lateral geniculate nucleus in 3-, 18-, 24-, and 28-month-old rats. The parameters analyzed were the capillary profile density, capillary volume fraction, length and surface area per unit volume, and capillary average diameter. The quantitative analysis showed in all parameters an increase between 3 and 18 months, and a significant decrease in capillary volume fraction (-18.75%) and diameter (-5.5%) between 18 and 24 months. No changes from 24 months onwards were observed. The increase observed in capillary profile density and capillary volume fraction between 3 and 18 months may indicate an increase of the capillary network. Furthermore, we observed an increase in the length and surface area per unit volume, which we interpret as an expansion of the exchange surface between blood and nerve tissue. The reduction in the capillary parameters that takes place between 18 and 24 months is slight, and may indicate the onset of decline characteristic of aging.
Authors:
Alicia Villena; Lourdes Vidal; Florentina Díaz; Ignacio Pérez De Vargas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology     Volume:  274     ISSN:  1552-4884     ISO Abbreviation:  -     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-08-18     Completed Date:  2004-05-21     Revised Date:  2004-12-15    
Medline Journal Info:
Nlm Unique ID:  101234285     Medline TA:  Anat Rec A Discov Mol Cell Evol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  857-61     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Wiley-Liss, Inc.
Affiliation:
Department of Histology and Pathology, School of Medicine, Campus de Teatinos, Málaga, Spain. avillena@uma.es
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology*
Animals
Capillaries / anatomy & histology,  growth & development*
Geniculate Bodies / blood supply*
Male
Rats
Rats, Wistar

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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