Document Detail

Stereological analysis of the hypothalamic hypocretin/orexin neurons in an animal model of depression.
MedLine Citation:
PMID:  15464197     Owner:  NLM     Status:  MEDLINE    
Affective disorders often occur in combination with disrupted sleep-wake cycles and abnormal fluctuations in hypothalamic neurotransmitters. Hypocretin (orexin) is a hypothalamic neuropeptide linked to narcolepsy, a sleep-related disorder characterized by profound disturbances in the normal sleeping pattern and variable degrees of depression. Wistar-Kyoto (WKY) rats exhibit depressive characteristics and patterns of sleep disruption similar to that observed in depressed human patients. In this study we sought to determine whether the total number or the size of hypothalamic hypocretin neurons in WKY rats differ from their control, Wistar (WIS) rats. Immunocytochemical and stereological methods were applied to quantify hypocretin-1 containing neurons in the hypothalamus. The study revealed 18% fewer hypocretin-1 positive neurons as well as a 15% decrease in average neuronal soma size of hypocretin-1 producing cells in the hypothalamus of WKY rats compared to WIS rats. These findings support the view that reduced number or size of hypothalamic hypocretinergic neurons may underlie the disrupted sleep pattern associated with depressive characteristics in WKY rats.
Joanne S Allard; Yousef Tizabi; James P Shaffery; C Ovid Trouth; Kebreten Manaye
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuropeptides     Volume:  38     ISSN:  0143-4179     ISO Abbreviation:  Neuropeptides     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-06     Completed Date:  2005-03-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8103156     Medline TA:  Neuropeptides     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  311-5     Citation Subset:  IM    
Department of Physiology and Biophysics, College of Medicine, Howard University, 520 W Street NW, Washington, DC 20059, USA.
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MeSH Terms
Cell Size
Depression* / metabolism,  pathology
Disease Models, Animal
Hypothalamus / cytology,  metabolism*
Intracellular Signaling Peptides and Proteins / metabolism*
Neurons / cytology,  metabolism*
Neuropeptides / metabolism*
Rats, Inbred WKY
Rats, Wistar
Sleep Disorders / metabolism,  pathology
Grant Support
Reg. No./Substance:
0/Intracellular Signaling Peptides and Proteins; 0/Neuropeptides; 0/orexins

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