Document Detail


Stereochemical and skeletal diversity arising from amino propargylic alcohols.
MedLine Citation:
PMID:  20481457     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An efficient synthetic pathway to the possible stereoisomers of skeletally diverse heterocyclic small molecules is presented. The change in shape brought about by different intramolecular cyclizations of diastereoisomeric amino propargylic alcohols is quantified using principal moment-of-inertia (PMI) shape analysis.
Authors:
Daniela Pizzirani; Taner Kaya; Paul A Clemons; Stuart L Schreiber
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Organic letters     Volume:  12     ISSN:  1523-7052     ISO Abbreviation:  Org. Lett.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-11     Completed Date:  2010-09-07     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2822-5     Citation Subset:  IM    
Affiliation:
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
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MeSH Terms
Descriptor/Qualifier:
Amino Alcohols / chemistry*
Cyclization
Heterocyclic Compounds with 4 or More Rings / chemical synthesis*,  chemistry
Molecular Structure
Stereoisomerism
Grant Support
ID/Acronym/Agency:
P50-GM069721/GM/NIGMS NIH HHS; //Howard Hughes Medical Institute
Chemical
Reg. No./Substance:
0/Amino Alcohols; 0/Heterocyclic Compounds with 4 or More Rings
Comments/Corrections

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