Document Detail


Stepwise synthesis of 2,3-<i>O</i>-dipalmitoyl-D-glyceric acid and an in vitro evaluation of its cytotoxicity.
MedLine Citation:
PMID:  22687779     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
2,3-O-Dipalmitoyl-D-glyceric acid (PA<inf>2</inf>-DGA) was synthesized from D-glyceric acid calcium salt and palmitoyl chloride with improved yield. Direct condensation between the D-glyceric acid calcium salt and palmitoyl chloride produced PA<inf>2</inf>-DGA with a yield of <10%, whereas stepwise synthesis yielded this compound at up to 24% of overall yield. PA<inf>2</inf>-DGA was then subjected to a cytotoxic test using normal human dermal fibroblasts and primary normal human dermal microvascular endothelial cells. This compound had no toxic effects on human cells in vitro at concentrations up to 34 µM.
Authors:
Shun Sato; Hiroshi Habe; Tokuma Fukuoka; Dai Kitamoto; Keiji Sakaki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of oleo science     Volume:  61     ISSN:  1347-3352     ISO Abbreviation:  J Oleo Sci     Publication Date:  2012  
Date Detail:
Created Date:  2012-06-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101175339     Medline TA:  J Oleo Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  337-41     Citation Subset:  IM    
Affiliation:
Research Institute for Innovation in Sustainable Chemistry, National Institute of Advanced Industrial Science and Technology (AIST).
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