Document Detail


Stepwise sequential aneuploidy screening in clinical practice.
MedLine Citation:
PMID:  22102396     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE.: To evaluate stepwise sequential screening (SSS) efficiency in clinical practice. METHODS.: All singletons undergoing SSS in a single practice by NTQR (Nuchal Translucency Quality Review Program)-credentialed providers in a 2-year period were included. Prenatal diagnosis was offered to all screen-positive women and those with a nuchal translucency ≥3.5 mm or cystic hygroma at the 11- to 14-week scan. Data were extracted from prospectively ascertained serum screening and genetics databases. RESULTS.: A total of 2,726 patients were screened, with SSS detecting all eight cases of trisomy 21 and all seven cases of other aneuploidies at a 4.3% screen-positive rate. CONCLUSIONS.: Stepwise sequential screening offers excellent aneuploidy screening efficiency when introduced into clinical practice. © 2011 Wiley Periodicals, Inc. J Clin Ultrasound, 2011.
Authors:
Joseph R Wax; Angelina Cartin; Dwight Smith; Rosemarie Smith; Renée Chard; Molly Carpenter; Michael G Pinette
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-21
Journal Detail:
Title:  Journal of clinical ultrasound : JCU     Volume:  -     ISSN:  1097-0096     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401663     Medline TA:  J Clin Ultrasound     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Wiley Periodicals, Inc.
Affiliation:
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Maine Medical Center, Portland, ME.
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