Document Detail

Steps of the coupled charge translocation in the catalytic cycle of cytochrome c oxidase.
MedLine Citation:
PMID:  23276908     Owner:  NLM     Status:  MEDLINE    
Cytochrome c oxidase (COX) terminates the respiratory chain in mitochondria and in plasmatic membrane of many aerobic bacteria. The enzyme reduces dioxygen molecule into water and the reaction is accompanied with generation of transmembrane difference of electric potentials. The energy conservation by COX is based on the vectorial organization of the chemical reaction due to substrate protons transfer from the negative phase into the active site to meet the electrons, coming from opposite side of the membrane. In addition, a half of free energy of redox-chemistry reaction is conserved through transmembrane proton pumping. Each of the reaction steps in the catalytic cycle of COX involves a sequence of coupled electron and proton transfer reaction. The time-resolved study of the coupled charge translocation during catalytic cycle of cytochrome c oxidase is reviewed. Based on many fascinating parallels between the mechanisms of COX and pigment-protein complex of photosystem II from oxygenic photosynthetic organisms, the data described could be used in the light-driven water-splitting process.
Sergey A Siletsky
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  18     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-06-12     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  36-57     Citation Subset:  IM    
A.N.Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow 119992, Russia.
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MeSH Terms
Electron Transport Complex IV / metabolism*
Models, Molecular
Proton Pumps / metabolism
Reg. No./Substance:
0/Proton Pumps; 0/Protons; EC Transport Complex IV

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