Document Detail


The Stephan Curve revisited.
MedLine Citation:
PMID:  23224410     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Stephan Curve has played a dominant role in caries research over the past several decades. What is so remarkable about the Stephan Curve is the plethora of interactions it illustrates and yet acid production remains the dominant focus. Using sophisticated technology, it is possible to measure pH changes in plaque; however, these observations may carry a false sense of accuracy. Recent observations have shown that there may be multiple pH values within the plaque matrix, thus emphasizing the importance of the milieu within which acid is formed. Although acid production is indeed the immediate proximate cause of tooth dissolution, the influence of alkali production within plaque has received relative scant attention. Excessive reliance on Stephan Curve leads to describing foods as "safe" if they do not lower the pH below the so-called "critical pH" at which point it is postulated enamel dissolves. Acid production is just one of many biological processes that occur within plaque when exposed to sugar. Exploration of methods to enhance alkali production could produce rich research dividends.
Authors:
William H Bowen
Publication Detail:
Type:  Journal Article; Review     Date:  2012-12-06
Journal Detail:
Title:  Odontology / the Society of the Nippon Dental University     Volume:  101     ISSN:  1618-1255     ISO Abbreviation:  Odontology     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-23     Completed Date:  2013-07-22     Revised Date:  2013-09-12    
Medline Journal Info:
Nlm Unique ID:  101134822     Medline TA:  Odontology     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  2-8     Citation Subset:  D; IM    
Affiliation:
Center for Oral Biology, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA. William_Bowen@urmc.rochester.edu
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MeSH Terms
Descriptor/Qualifier:
Acids / adverse effects,  metabolism*
Alkalies / metabolism
Dental Caries / etiology,  metabolism*
Dental Enamel / drug effects*
Dental Plaque / metabolism*
Humans
Hydrogen-Ion Concentration
Tooth Wear / etiology
Chemical
Reg. No./Substance:
0/Acids; 0/Alkalies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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