| Stent thrombosis in the modern era: a pooled analysis of multicenter coronary stent clinical trials. | |
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MedLine Citation:
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PMID: 11306525 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: There are limited studies of stent thrombosis in the modern era of second-generation stents, high-pressure deployment, and current antithrombotic regimens. METHODS AND RESULTS: Six recently completed coronary stent trials and associated nonrandomized registries that enrolled 6186 patients (6219 treated vessels) treated with >/=1 coronary stent followed by antiplatelet therapy with aspirin and ticlopidine were pooled for this analysis. Within 30 days, clinical stent thrombosis developed in 53 patients (0.9%). The variables most significantly associated with the probability of stent thrombosis were persistent dissection NHLBI grade B or higher after stenting (OR, 3.7; 95% CI, 1.9 to 7.7), total stent length (OR, 1.3; 95% CI, 1.2 to 1.5 per 10 mm), and final minimal lumen diameter within the stent (OR, 0.4; 95% CI, 0.2 to 0.7 per 1 mm). Stent thrombosis was documented by angiography in 45 patients (0.7%). Clinical consequences of angiographic stent thrombosis included 64.4% incidence of death or myocardial infarction at the time of stent thrombosis and 8.9% 6-month mortality. CONCLUSIONS: Stent thrombosis occurred in <1.0% of patients undergoing stenting of native coronary artery lesions and receiving routine antiplatelet therapy with aspirin plus ticlopidine. Procedure-related variables of persistent dissection, total stent length, and final lumen diameter were significantly associated with the probability of stent thrombosis. Continued efforts to eliminate this complication are warranted given the serious clinical consequences. |
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Authors:
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D E Cutlip; D S Baim; K K Ho; J J Popma; A J Lansky; D J Cohen; J P Carrozza; M S Chauhan; O Rodriguez; R E Kuntz |
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Publication Detail:
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Type: Journal Article; Meta-Analysis |
Journal Detail:
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Title: Circulation Volume: 103 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2001 Apr |
Date Detail:
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Created Date: 2001-04-18 Completed Date: 2001-05-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: United States |
Other Details:
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Languages: eng Pagination: 1967-71 Citation Subset: IM |
Affiliation:
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University of Rochester Medical Center, Rochester, NY, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aspirin
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therapeutic use Blood Vessel Prosthesis Implantation Causality Coronary Disease / drug therapy, surgery Coronary Thrombosis / epidemiology*, mortality Endpoint Determination Female Graft Occlusion, Vascular / epidemiology*, mortality Humans Incidence Logistic Models Male Middle Aged Multicenter Studies as Topic Myocardial Revascularization Odds Ratio Platelet Aggregation Inhibitors / therapeutic use Randomized Controlled Trials as Topic Survival Rate Ticlopidine / therapeutic use Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Platelet Aggregation Inhibitors; 50-78-2/Aspirin; 55142-85-3/Ticlopidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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