Document Detail


Stent-induced coronary artery stenosis characterized by multimodal nonlinear optical microscopy.
MedLine Citation:
PMID:  21361673     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We demonstrate for the first time the applicability of multimodal nonlinear optical (NLO) microscopy to the interrogation of stented coronary arteries under different diet and stent deployment conditions. Bare metal stents and Taxus drug-eluting stents (DES) were placed in coronary arteries of Ossabaw pigs of control and atherogenic diet groups. Multimodal NLO imaging was performed to inspect changes in arterial structures and compositions after stenting. Sum frequency generation, one of the multimodalities, was used for the quantitative analysis of collagen content in the peristent and in-stent artery segments of both pig groups. Atherogenic diet increased lipid and collagen in peristent segments. In-stent segments showed decreased collagen expression in neointima compared to media. Deployment of DES in atheromatous arteries inhibited collagen expression in the arterial media.
Authors:
Han-Wei Wang; Vlad Simianu; Mattew J Locker; Ji-Xin Cheng; Michael Sturek
Related Documents :
3046073 - Reversible cerebral segmental vasoconstriction.
12452133 - Preoperative ventriculostomy and rebleeding after aneurysmal subarachnoid hemorrhage.
12588783 - Bicuspid aortic valve associated with aortic dilatation: a community-based study.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biomedical optics     Volume:  16     ISSN:  1560-2281     ISO Abbreviation:  J Biomed Opt     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-03-02     Completed Date:  2011-06-02     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  9605853     Medline TA:  J Biomed Opt     Country:  United States    
Other Details:
Languages:  eng     Pagination:  021110     Citation Subset:  IM    
Affiliation:
Purdue University, Weldon School of Biomedical Engineering, West Lafayette, Indiana 47907, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Blood Vessel Prosthesis / adverse effects*
Coronary Stenosis / etiology*,  pathology*
Image Enhancement / methods*
Microscopy, Confocal / methods*
Nonlinear Dynamics
Stents / adverse effects*
Swine
Grant Support
ID/Acronym/Agency:
HL062552/HL/NHLBI NIH HHS; R01 EB007243/EB/NIBIB NIH HHS; RR013223/RR/NCRR NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Multimodal coherent anti-Stokes Raman scattering microscopy reveals microglia-associated myelin and ...
Next Document:  Real-time imaging of laser-induced membrane disruption of a living cell observed with multifocus coh...