Document Detail


Stent implantation in coronary porcine arteries is associated with early activation of TNFalpha and TNFalpha receptor II expression.
MedLine Citation:
PMID:  16857205     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Inflammation present in restenosis after angioplasty is associated with production of cytokines such as tumor necrosis factor (TNFalpha). However, limited data exist on the possible increase in TNFalpha and TNFalpha receptor expression induced during the chronic phase after stenting. To this end, swine underwent balloon denudation (PTCA) and stent implantation in coronary arteries. At day 1, 7 or 28 post-procedure, sections from injured and reference vessel segments were evaluated for extent of pathology and expression of TNFalpha and TNFalpha receptors (RI and RII). Restenosis assessed at days 7 and 28 showed, respectively, two- and six-fold more neointimal (NI) area in stented than in PTCA segments. Unlike reference segments, TNFalpha-positive cells were detected in both the media and the NI of injured segments, with a significant increase over the 28-day time frame. Stenting was associated with an eight-fold enhancement in TNFalpha expression over PTCA. TNFalpha expression and NI area tended to correlate in injured segments. Furthermore, the pattern of expression of TNFalpha-RII, but not TNFalpha-RI, resembled that of TNFalpha itself. These results implicate TNFalpha and TNFalpha-RII as important actors in both the acute and the chronic phases of inflammation following stent implantation.
Authors:
Sofiane Hadjadj; Isabelle Cloutier; Pascale Geoffroy; Jean-François Tanguay
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2006-07-20
Journal Detail:
Title:  Atherosclerosis     Volume:  192     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-24     Completed Date:  2007-07-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  25-32     Citation Subset:  IM    
Affiliation:
Research Center, Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada.
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MeSH Terms
Descriptor/Qualifier:
Angioplasty, Transluminal, Percutaneous Coronary / adverse effects*
Animals
Coronary Restenosis / immunology
Coronary Vessels / immunology*,  injuries*
Disease Models, Animal
Immunohistochemistry
Inflammation
Receptors, Tumor Necrosis Factor, Type I / metabolism
Receptors, Tumor Necrosis Factor, Type II / metabolism*
Stents / adverse effects*
Sus scrofa
Tumor Necrosis Factor-alpha / metabolism*
Tunica Intima / growth & development,  immunology
Up-Regulation / immunology
Chemical
Reg. No./Substance:
0/Receptors, Tumor Necrosis Factor, Type I; 0/Receptors, Tumor Necrosis Factor, Type II; 0/Tumor Necrosis Factor-alpha

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