| Stem cells used for cardiovascular tissue engineering. | |
| | |
MedLine Citation:
|
PMID: 18468449 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Stem cell research and tissue engineering have become leading fields in basic research worldwide. Especially in cardiovascular medicine, initial reports on the potential of using stem cells to recover cardiac function and replace organ subunits such as heart valves seemed to offer the promise of widespread clinical use in the near future. However, the broad application of this new therapy failed due to safety and efficacy concerns. Due in part to the initial reports, major basic research efforts were undertaken to explore the specific cell types in greater detail and identify their mechanisms of supporting function, resulting in remarkable new findings in stem cell biology. For example, the notion of resident human cardiac stem cells has disproved the earlier supposition that the human heart is a finitely differentiated organ without the intrinsic potential for regeneration. Furthermore, new technologies emerged to produce pluripotent cells without the ethical and immunological drawbacks of embryonic stem cells (for instance by nuclear transfer). Other autologous cell sources are presently under investigation in myocardial tissue engineering. For tissue engineering of heart valves and small calibre vessels, the use of autologous endothelial (precursor) cells may be the optimal means of seeding a biological or artificial scaffold. It is important that ongoing basic and clinical research in cardiovascular surgery might explore the potential of different cell types either using tissue engineering constructs or in cell transplantation approaches. |
| | |
Authors:
|
Matthias Siepe; Payam Akhyari; Artur Lichtenberg; Christian Schlensak; Friedhelm Beyersdorf |
Related Documents
:
|
23060879 - Novel microchip-based tools facilitating live cell imaging and assessment of functional... 23278749 - The establishment of the plasma cell survival niche in the bone marrow. 23552359 - Granulomatous inflammation in acanthamoeba sclerokeratitis. 23733329 - Natural killer cell-activating receptor nkg2d mediates innate immune targeting of allog... 23409179 - Homeostatic properties and phenotypic maturation of murine cd4(+) pre-thymic emigrants ... 22986949 - Maraviroc intensification of stable antiviral therapy in hiv-1-infected patients with p... 10611899 - Bone marrow: target for gene transfer. 2962929 - T lymphocytes emigrating from the thymus to the spleen during postpartum regulate serum... 11973649 - Differential regulation of the response to dna damage in ewing's sarcoma cells by ets1 ... |
Publication Detail:
|
Type: Journal Article; Review Date: 2008-05-08 |
Journal Detail:
|
Title: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery Volume: 34 ISSN: 1010-7940 ISO Abbreviation: Eur J Cardiothorac Surg Publication Date: 2008 Aug |
Date Detail:
|
Created Date: 2008-07-14 Completed Date: 2009-03-03 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8804069 Medline TA: Eur J Cardiothorac Surg Country: Germany |
Other Details:
|
Languages: eng Pagination: 242-7 Citation Subset: IM |
Affiliation:
|
Department of Cardiovascular Surgery, University Clinic Freiburg, Hugstetterstrasse 55, Freiburg, Germany. matthias.siepe@web.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Bioartificial Organs Blood Vessel Prosthesis* Endothelium, Vascular / cytology Heart Valve Prosthesis* Heart Valve Prosthesis Implantation / methods Humans Regeneration Stem Cell Transplantation / methods Tissue Engineering / methods* |
| Comments/Corrections | |
Comment In:
|
Eur J Cardiothorac Surg. 2008 Aug;34(2):227-8
[PMID:
18585049
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Late reoperations after neonatal arterial switch operation for transposition of the great arteries.
Next Document: A theoretical study on the quenching mechanisms of triplet state riboflavin by tryptophan and tyrosi...