| Stem cells in the diabetic infarcted heart. | |
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MedLine Citation:
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PMID: 20559720 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Diabetes mellitus is one of the leading causes of death, and the majority of these deaths are associated with cardiovascular diseases. Development and progression of myocardial infarction leading to heart failure is much more complex and multifactorial in diabetics compared with non-diabetics. Despite significant advances in pharmacological interventions and surgical techniques, the disease progression leading to diabetic end-stage heart failure remains very high. Recently, cell therapy has gained much attention as an alternative approach to treat various heart diseases. However, transplanted stem cell studies in diabetic animal models are very limited. In this review, we discuss the pathogenesis of the diabetic infarcted heart and the potential of stem cell therapy to repair and regenerate. |
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Authors:
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Carley E Glass; Pawan K Singal; Dinender K Singla |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Heart failure reviews Volume: 15 ISSN: 1573-7322 ISO Abbreviation: Heart Fail Rev Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2011-02-08 Revised Date: 2011-11-01 |
Medline Journal Info:
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Nlm Unique ID: 9612481 Medline TA: Heart Fail Rev Country: United States |
Other Details:
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Languages: eng Pagination: 581-8 Citation Subset: IM |
Affiliation:
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Biomolecular Science Center, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, 4000 Central Florida BLVD, Room 224, Orlando, FL 32816, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diabetes Complications / metabolism, physiopathology*, surgery Heart Failure / etiology, physiopathology, surgery* Humans Hyperglycemia / complications, physiopathology Insulin Resistance Metabolic Syndrome X / complications, physiopathology Myocardial Infarction / etiology, physiopathology, surgery* Myocytes, Cardiac / transplantation* Oxidative Stress Stem Cell Transplantation* Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
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1R01HL090646-01/HL/NHLBI NIH HHS; 1R21 HL085795-01A1/HL/NHLBI NIH HHS; R01 HL090646-02/HL/NHLBI NIH HHS; R21 HL085795-02/HL/NHLBI NIH HHS |
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