Document Detail

Stem cells in cardiac repair.
MedLine Citation:
PMID:  16483849     Owner:  NLM     Status:  MEDLINE    
Advances in the treatment of acute myocardial infarction have led to increased survival but also an increase in those suffering from heart failure. The concept of adult progenitor cell therapy has grown from observations that cardiac function improves after injection of bone marrow-derived cells into infarcted regions in animal models. The mechanism of action is unclear and is probably multifactorial. Different subpopulations of autologous cells have been utilised in humans with acute myocardial infarction and heart failure, as well different routes of delivery. These small Phase I clinical trials suggest that this approach is safe and leads to clinical improvement, and larger scale randomised control studies are underway. We believe that cell therapy heralds a revolutionary new era in the treatment of disease.
Nicholas F Grigoropoulos; Anthony Mathur
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Publication Detail:
Type:  Journal Article; Review     Date:  2006-02-17
Journal Detail:
Title:  Current opinion in pharmacology     Volume:  6     ISSN:  1471-4892     ISO Abbreviation:  Curr Opin Pharmacol     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-13     Completed Date:  2006-08-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100966133     Medline TA:  Curr Opin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  169-75     Citation Subset:  IM    
Cardiac Research Department, The London Chest Hospital, Bonner Road, London E2 9JX, UK.
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MeSH Terms
Bone Marrow Transplantation*
Clinical Trials, Phase I as Topic
Disease Models, Animal
Heart Failure / therapy*
Myocardial Infarction / therapy*
Neovascularization, Physiologic
Stem Cell Transplantation*

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