Document Detail


Stem cell transplantation in chronic lymphocytic leukaemia - steering a safe course over shifting sands.
MedLine Citation:
PMID:  20620975     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is no clear consensus regarding the optimal management of chronic lymphocytic leukaemia. Many patients are diagnosed at an advanced age and will die with chronic lymphocytic leukaemia, but of other unrelated causes. A significant minority are diagnosed at an earlier age, or with more aggressive disease, and despite chemotherapy, are likely to die of chronic lymphocytic leukaemia. The infusion of autologous or allogeneic haemopoietic stem cells, following a variety of conditioning regimes, offers the possibility of longer remissions or even cure. We explore the key questions facing clinicians in this field: Who is it best to transplant? When is it best to transplant? How is it best to transplant?
Authors:
Simon Hallam; John G Gribben
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Best practice & research. Clinical haematology     Volume:  23     ISSN:  1532-1924     ISO Abbreviation:  Best Pract Res Clin Haematol     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-07-12     Completed Date:  2011-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101120659     Medline TA:  Best Pract Res Clin Haematol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  109-19     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Institute of Cancer, Bart's and the London School of Medicine, Charterhouse Square, London, EC1M 6BQ, UK.
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MeSH Terms
Descriptor/Qualifier:
Hematopoietic Stem Cell Transplantation*
Humans
Leukemia, Lymphocytic, Chronic, B-Cell / diagnosis,  therapy*
Transplantation, Autologous
Transplantation, Homologous

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