Document Detail

Stem cell therapy for joint problems using the horse as a clinically relevant animal model.
MedLine Citation:
PMID:  17961087     Owner:  NLM     Status:  MEDLINE    
Research into articular cartilage is a surprisingly recent endeavour and much remains to be learned about the normal development of the synovial joint and its components that interplay in osteoarthritis and focal cartilage defects. Stem cell research is likely to contribute to the understanding of the developmental biology of synovial joints and their pathologies. Before human clinical trials are undertaken, stem cell-based therapies for non-life threatening disorders should be evaluated for their safety and efficacy using animal models of spontaneous disease and not solely by the existing laboratory models of experimentally induced lesions. The horse lends itself as a good animal model of spontaneous joint disorders that are clinically relevant to similar human disorders. Equine stem cell and tissue engineering studies may be financially feasible to principal investigators and small biotechnology companies if the equine industry is successfully engaged in the research process.
Thomas G Koch; Dean H Betts
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Expert opinion on biological therapy     Volume:  7     ISSN:  1744-7682     ISO Abbreviation:  Expert Opin Biol Ther     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-26     Completed Date:  2007-11-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101125414     Medline TA:  Expert Opin Biol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  1621-6     Citation Subset:  IM    
University of Guelph, Department of Biomedical Sciences, Ontario Veterinary College, Guelph, ON, N1G 2W1, Canada.
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MeSH Terms
Disease Models, Animal*
Horse Diseases / therapy*
Joint Diseases / therapy,  veterinary*
Stem Cell Transplantation*

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