Document Detail


Stem cell therapy in veterinary dermatology.
MedLine Citation:
PMID:  23331685     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Adult stem cells come from many sources and have the capacity to differentiate into many cell types, including those of the skin. The most commonly studied stem cells are those termed mesenchymal stem cells (MSCs), which are easily isolated from bone marrow and adipose tissue. Mesenchymal stem cells are known to produce a wide array of cytokines that modulate the regeneration process. The ease of collection, propagation and use of these MSCs in therapy of traumatic, ischaemic and immune-mediated skin conditions is emerging.
APPROACH AND EVIDENCE: In traumatic and ischaemic skin damage, MSCs are used in tissue-engineered skin and by direct injection into damaged tissue. For immune-mediated diseases, systemic administration of stem cells can modulate the immune system. The earliest clinical work has been with autologous stem cell sources, such as adipose tissue and bone marrow. In immune-mediated diseases, the MSCs are used to downregulate production of inflammatory cytokines and to block T-cell activation. Cells are generally given intravenously. Multiple sclerosis, rheumatoid arthritis and lupus have been successfully treated in human clinical trials. Mesenchymal stem cells can also stimulate resident local cells, such as keratinocytes and progenitor cells, to proliferate, migrate and repair skin injury and disease.
LOOKING AHEAD: The discovery of the MSC in adipose tissue has spawned a global effort to utilize these cells in therapy of a wide range of diseases of the skin. Reconstructive surgery, scar blocking and resolution and skin regeneration have all been shown to be possible in human and animal studies.
Authors:
Robert J Harman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Veterinary dermatology     Volume:  24     ISSN:  1365-3164     ISO Abbreviation:  Vet. Dermatol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-21     Completed Date:  2013-07-03     Revised Date:  2013-07-15    
Medline Journal Info:
Nlm Unique ID:  9426187     Medline TA:  Vet Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  90-6.e23-4     Citation Subset:  IM    
Copyright Information:
© 2013 The Author. Veterinary Dermatology © 2013 ESVD and ACVD.
Affiliation:
Vet-Stem, Inc., 12860 Danielson Court, Poway, CA 82064, USA. bharman@vet-stem.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Dermatology / methods*,  trends
Skin Diseases / therapy,  veterinary*
Stem Cell Transplantation / veterinary*
Stem Cells / physiology
Veterinary Medicine / methods*

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