Document Detail


Stem cell reprogramming as a driver of basal cell carcinoma.
MedLine Citation:
PMID:  23196843     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Basal cell carcinoma has been shown to originate from activation of hedgehog signalling in interfollicular epidermal progenitor cells. Analyses of the early steps of basal cell carcinoma formation show that this process requires reprogramming of interfolliclular epidermal cells to an embryonic hair follicle progenitor-like fate, with concomitant Wnt pathway activation.
Authors:
David W M Tan; Nick Barker
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nature cell biology     Volume:  14     ISSN:  1476-4679     ISO Abbreviation:  Nat. Cell Biol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890575     Medline TA:  Nat Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1246-7     Citation Subset:  IM    
Affiliation:
Institute of Medical Biology, 8A Biomedical Grove, 06-06 Immunos, 138648 Singapore.
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