| Stem cell pluripotency: a cellular trait that depends on transcription factors, chromatin state and a checkpoint deficient cell cycle. | |
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MedLine Citation:
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PMID: 19562686 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Embryonic stem (ES) and induced pluripotent stem (iPS) cells self-renew and are pluripotent. Differentiation of these cells can yield over 200 somatic cell types, making pluripotent cells an obvious source for regenerative medicine. Before the potential of these cells can be maximally harnessed for clinical applications, it will be necessary to understand the processes that maintain pluripotentiality and signal differentiation. Currently, three unique molecular properties distinguish pluripotent stem cells from somatic cells. These include a unique transcriptional hierarchy that sustains the pluripotent state during the process of self-renewal; a poised epigenetic state that maintains chromatin in a form ready for rapid cell fate decisions; and a cell cycle characterized by an extremely short gap 1 (G1) phase and the near absence of normal somatic cell checkpoint controls. Recently, B-MYB (MYBL2) was implicated in the gene regulation of two pluripotency factors and normal cell cycle progression. In this article, the three pluripotency properties and the potential role of B-Myb to regulate these processes will be discussed. |
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Authors:
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Kenneth R Boheler |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural; Review |
Journal Detail:
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Title: Journal of cellular physiology Volume: 221 ISSN: 1097-4652 ISO Abbreviation: J. Cell. Physiol. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-07-29 Completed Date: 2009-08-28 Revised Date: 2012-04-18 |
Medline Journal Info:
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Nlm Unique ID: 0050222 Medline TA: J Cell Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 10-7 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Wiley-Liss, Inc. |
Affiliation:
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National Institute on Aging, NIH, Baltimore, Maryland 21224, USA. bohelerk@grc.nia.nih.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle* Chromatin / metabolism* Epigenesis, Genetic Humans Pluripotent Stem Cells / cytology*, metabolism* Transcription Factors / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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Z01 AG000847-01/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Chromatin; 0/Transcription Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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