Document Detail


Stem cell mechanisms during left ventricular remodeling post-myocardial infarction: Repair and regeneration.
MedLine Citation:
PMID:  25068021     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Post-myocardial infarction (MI), the left ventricle (LV) undergoes a series of events collectively referred to as remodeling. As a result, damaged myocardium is replaced with fibrotic tissue consequently leading to contractile dysfunction and ultimately heart failure. LV remodeling post-MI includes inflammatory, fibrotic, and neovascularization responses that involve regulated cell recruitment and function. Stem cells (SCs) have been transplanted post-MI for treatment of LV remodeling and shown to improve LV function by reduction in scar tissue formation in humans and animal models of MI. The promising results obtained from the application of SCs post-MI have sparked a massive effort to identify the optimal SC for regeneration of cardiomyocytes and the paradigm for clinical applications. Although SC transplantations are generally associated with new tissue formation, SCs also secrete cytokines, chemokines and growth factors that robustly regulate cell behavior in a paracrine fashion during the remodeling process. In this review, the different types of SCs used for cardiomyogenesis, markers of differentiation, paracrine factor secretion, and strategies for cell recruitment and delivery are addressed.
Authors:
Rogelio Zamilpa; Mary M Navarro; Iris Flores; Sy Griffey
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  World journal of cardiology     Volume:  6     ISSN:  1949-8462     ISO Abbreviation:  World J Cardiol     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-07-28     Completed Date:  2014-07-28     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  101537090     Medline TA:  World J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  610-20     Citation Subset:  -    
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