Document Detail


Stem cell factor enhances the growth of primitive erythroid progenitors to a greater extent than interleukin-3 in patients with aplastic anaemia.
MedLine Citation:
PMID:  7522518     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined the combined effects of stem cell factor (SCF), or interleukin-3 (IL-3) with erythropoietin on the development of haemopoietic progenitors in 19 patients with aplastic anaemia (AA) and eight normal controls by using an in vitro clonal assay. SCF significantly enhanced the growth of total erythroid colonies (erythroid bursts, mixed colonies) in 11 patients and all normal controls, whereas IL-3 did so in only three patients. The number of SCF- or IL-3-dependent erythroid colonies was substantially lower in AA patients than in the controls. Comparison of the capacity of SCF and IL-3 to increase total erythroid colony growth indicated that half of the AA patients responded more strongly to SCF than the normal controls, while few patients responded in such a manner to IL-3. These findings suggest that SCF in vivo will have a more dramatic effect than IL-3 in improving anaemia in patients with AA.
Authors:
Y Amano; K Koike; T Nakahata
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  British journal of haematology     Volume:  85     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-10-26     Completed Date:  1994-10-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  663-9     Citation Subset:  IM    
Affiliation:
Department of Paediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anemia, Aplastic / blood*,  pathology
Cell Division
Child
Child, Preschool
Colony-Forming Units Assay
Dose-Response Relationship, Drug
Erythroid Precursor Cells / drug effects*,  pathology
Erythropoietin / pharmacology*
Female
Hematopoietic Cell Growth Factors / pharmacology*
Humans
Interleukin-3 / pharmacology*
Male
Stem Cell Factor
Chemical
Reg. No./Substance:
0/Hematopoietic Cell Growth Factors; 0/Interleukin-3; 0/Stem Cell Factor; 11096-26-7/Erythropoietin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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