| Stem cell-based therapies for osteoarthritis: challenges and opportunities. | |
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MedLine Citation:
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PMID: 23190869 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: Regenerative medicine offers the exciting potential of developing alternatives to total joint replacement for treating osteoarthritis. In this article, we highlight recent work that addresses key challenges of stem cell-based therapies for osteoarthritis and provide examples of innovative ways in which stem cells can aid in the treatment of osteoarthritis. RECENT FINDINGS: Significant progress has been made in understanding the challenges to successful stem cell therapy, such as the effects of age or disease on stem cell properties, altered stem cell function due to an inflammatory joint environment and phenotypic instability in vivo. Novel scaffold designs have been shown to enhance the mechanical properties of tissue-engineered cartilage and have also improved the integration of newly formed tissue within the joint. Emerging strategies such as injecting stem cells directly into the joint, manipulating endogenous stem cells to enhance regenerative capacity and utilizing stem cells for drug discovery have expanded the potential uses of stem cells in treating osteoarthritis. SUMMARY: Several recent studies have greatly advanced the development and preclinical evaluation of potential stem cell-based treatments for osteoarthritis through novel approaches focused on cell therapy, tissue engineering and drug discovery. |
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Authors:
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Brian O Diekman; Farshid Guilak |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current opinion in rheumatology Volume: 25 ISSN: 1531-6963 ISO Abbreviation: Curr Opin Rheumatol Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2012-11-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9000851 Medline TA: Curr Opin Rheumatol Country: United States |
Other Details:
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Languages: eng Pagination: 119-26 Citation Subset: IM |
Affiliation:
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aDepartment of Orthopaedic Surgery bDepartment of Biomedical Engineering, Duke University Medical Center and Duke University, Durham, North Carolina, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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