Document Detail


Stem cell-based therapies for osteoarthritis: challenges and opportunities.
MedLine Citation:
PMID:  23190869     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: Regenerative medicine offers the exciting potential of developing alternatives to total joint replacement for treating osteoarthritis. In this article, we highlight recent work that addresses key challenges of stem cell-based therapies for osteoarthritis and provide examples of innovative ways in which stem cells can aid in the treatment of osteoarthritis.
RECENT FINDINGS: Significant progress has been made in understanding the challenges to successful stem cell therapy, such as the effects of age or disease on stem cell properties, altered stem cell function due to an inflammatory joint environment and phenotypic instability in vivo. Novel scaffold designs have been shown to enhance the mechanical properties of tissue-engineered cartilage and have also improved the integration of newly formed tissue within the joint. Emerging strategies such as injecting stem cells directly into the joint, manipulating endogenous stem cells to enhance regenerative capacity and utilizing stem cells for drug discovery have expanded the potential uses of stem cells in treating osteoarthritis.
SUMMARY: Several recent studies have greatly advanced the development and preclinical evaluation of potential stem cell-based treatments for osteoarthritis through novel approaches focused on cell therapy, tissue engineering and drug discovery.
Authors:
Brian O Diekman; Farshid Guilak
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Current opinion in rheumatology     Volume:  25     ISSN:  1531-6963     ISO Abbreviation:  Curr Opin Rheumatol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-11-29     Completed Date:  2013-05-17     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  9000851     Medline TA:  Curr Opin Rheumatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  119-26     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aging / pathology
Drug Evaluation, Preclinical / methods
Humans
Osteoarthritis / pathology,  therapy*
Stem Cell Transplantation / methods*,  trends
Stem Cells / physiology
Tissue Engineering / methods
Tissue Scaffolds
Grant Support
ID/Acronym/Agency:
AG15768/AG/NIA NIH HHS; AR48182/AR/NIAMS NIH HHS; AR48852/AR/NIAMS NIH HHS; AR50245/AR/NIAMS NIH HHS; P01 AR050245/AR/NIAMS NIH HHS; R01 AG015768/AG/NIA NIH HHS; R01 AR048182/AR/NIAMS NIH HHS; R01 AR048852/AR/NIAMS NIH HHS
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