Document Detail


Stem cell applications in tendon disorders: a clinical perspective.
MedLine Citation:
PMID:  22448174     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Tendon injuries are a common cause of morbidity and a significant health burden on society. Tendons are structural tissues connecting muscle to bone and are prone to tearing and tendinopathy, an overuse or degenerative condition that is characterized by failed healing and cellular depletion. Current treatments, for tendon tear are conservative, surgical repair or surgical scaffold reconstruction. Tendinopathy is treated by exercises, injection therapies, shock wave treatments or surgical tendon debridement. However, tendons usually heal with fibrosis and scar tissue, which has suboptimal tensile strength and is prone to reinjury, resulting in lifestyle changes with activity restriction. Preclinical studies show that cell therapies have the potential to regenerate rather than repair tendon tissue, a process termed tenogenesis. A number of different cell lines, with varying degrees of differentiation, have being evaluated including stem cells, tendon derived cells and dermal fibroblasts. Even though cellular therapies offer some potential in treating tendon disorders, there have been few published clinical trials to determine the ideal cell source, the number of cells to administer, or the optimal bioscaffold for clinical use.
Authors:
Mark Young
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Publication Detail:
Type:  Journal Article     Date:  2012-01-29
Journal Detail:
Title:  Stem cells international     Volume:  2012     ISSN:  1687-9678     ISO Abbreviation:  Stem Cells Int     Publication Date:  2012  
Date Detail:
Created Date:  2012-03-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101535822     Medline TA:  Stem Cells Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  637836     Citation Subset:  -    
Affiliation:
Department of Biotherapies, Mater Medical Research Institute, Aubigny Place, Raymond Terrace, South Brisbane, QLD 4101, Australia.
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