Document Detail


Stem Cells in Human Endometrium and Endometrial Carcinoma.
MedLine Citation:
PMID:  21623195     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This study reviews the current knowledge about endometrial somatic stem cells and endometrial cancer stem cells. It describes the main features of somatic stem cells, such as high proliferative potential, self renewal, differentiation into 1 or more lineages, retention of a DNA synthesis label (BrdU), and some methods to identify them (Hoechst dye exclusion test, immunophenotyping). The most likely markers for endometrial somatic stem cells (Oct-4, Musashi-1, CD31, CD34, and CD144) are also mentioned. The study also reviews the literature regarding endometrial cancer stem cells. Results obtained by evaluation of the side population in endometrial cancer cell lines and studies on putative cancer stem cell markers are also discussed. The possible roles of endometrial cancer stem cells in metastasis and resistance to anticancer treatment are also mentioned.
Authors:
Irene Cervelló; Cristina Mirantes; Xavier Santamaria; Xavier Dolcet; Xavier Matias-Guiu; Carlos Simón
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-26
Journal Detail:
Title:  International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists     Volume:  -     ISSN:  1538-7151     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8214845     Medline TA:  Int J Gynecol Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Fundación IVI (I.C., X.S., C.S.), Instituto Universitario IVI, Valencia University, Incliva Stem Cell Bank (C.S.), Centro de Investigación Príncipe Felipe, Valencia Department of Pathology and Molecular Genetics and Research Laboratory (C.M., X.D., X.M.), Hospital Universitari Arnau de Vilanova, University of Lleida, IRBLLEIDA, Lleida, Spain.
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