| Stem Cells in Human Endometrium and Endometrial Carcinoma. | |
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MedLine Citation:
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PMID: 21623195 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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This study reviews the current knowledge about endometrial somatic stem cells and endometrial cancer stem cells. It describes the main features of somatic stem cells, such as high proliferative potential, self renewal, differentiation into 1 or more lineages, retention of a DNA synthesis label (BrdU), and some methods to identify them (Hoechst dye exclusion test, immunophenotyping). The most likely markers for endometrial somatic stem cells (Oct-4, Musashi-1, CD31, CD34, and CD144) are also mentioned. The study also reviews the literature regarding endometrial cancer stem cells. Results obtained by evaluation of the side population in endometrial cancer cell lines and studies on putative cancer stem cell markers are also discussed. The possible roles of endometrial cancer stem cells in metastasis and resistance to anticancer treatment are also mentioned. |
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Authors:
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Irene Cervelló; Cristina Mirantes; Xavier Santamaria; Xavier Dolcet; Xavier Matias-Guiu; Carlos Simón |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-26 |
Journal Detail:
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Title: International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists Volume: - ISSN: 1538-7151 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8214845 Medline TA: Int J Gynecol Pathol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Fundación IVI (I.C., X.S., C.S.), Instituto Universitario IVI, Valencia University, Incliva Stem Cell Bank (C.S.), Centro de Investigación Príncipe Felipe, Valencia Department of Pathology and Molecular Genetics and Research Laboratory (C.M., X.D., X.M.), Hospital Universitari Arnau de Vilanova, University of Lleida, IRBLLEIDA, Lleida, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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