| Stem cells, differentiation and cell cycle control in pituitary. | |
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MedLine Citation:
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PMID: 20616491 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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As model of organogenesis, the pituitary gland is a relatively simple tissue; yet, we understand little of the mechanisms that determine organ size, cell number and allocation of cells to different lineages. While the discovery of cell-restricted transcription factors has led to significant insight into the mechanisms controlling differentiation and cell-specific gene expression, we still need to integrate these processes with control of organ development. The identification of pituitary stem cells has suggested mechanisms for maintenance of adult pituitary but these findings again highlight the crucial role of cell cycle control for determination of progenitor and differentiated cell numbers. We recently described the mechanisms for progenitor cell cycle exit in early pituitary development that critically depend on the cell cycle inhibitor p57Kip2. It appears that cell cycle control is independent of differentiation, indicating that separate regulatory mechanisms must be involved in each process. The role of p57Kip2 appears to be restricted to progenitor cell cycle exit and it is rather the related p27Kip1 that prevents re-entry into the cycle of differentiated cells. While these data revealed a new transient intermediate between progenitors and differentiated cells, they also raised new questions and suggested that separate signals may control differentiation and cell cycle. |
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Authors:
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Jacques Drouin; Steve Bilodeau; Audrey Roussel-Gervais |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-07-05 |
Journal Detail:
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Title: Frontiers of hormone research Volume: 38 ISSN: 0301-3073 ISO Abbreviation: Front Horm Res Publication Date: 2010 |
Date Detail:
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Created Date: 2010-07-09 Completed Date: 2010-09-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0320246 Medline TA: Front Horm Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 15-24 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 S. Karger AG, Basel. |
Affiliation:
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Institut de Recherches Cliniques de Montréal (IRCM), Montréal, QC, Canada. jacques.drouin@ircm.qc.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle* Cell Differentiation* Cyclin-Dependent Kinase Inhibitor p57 / physiology Homeodomain Proteins / physiology Humans Intracellular Signaling Peptides and Proteins / physiology Pituitary Gland / embryology* Stem Cells / cytology* T-Box Domain Proteins / physiology |
| Grant Support | |
ID/Acronym/Agency:
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//Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
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0/CDKN1B protein, human; 0/CDKN1C protein, human; 0/Cyclin-Dependent Kinase Inhibitor p57; 0/Homeodomain Proteins; 0/Intracellular Signaling Peptides and Proteins; 0/T-Box Domain Proteins; 0/TBX19 protein, human |
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