Document Detail

Stem cell therapy remediates reconstruction of the craniofacial skeleton after radiation therapy.
MedLine Citation:
PMID:  23282102     Owner:  NLM     Status:  MEDLINE    
This study utilized transplanted bone marrow stromal cells (BMSCs) as a cellular replacement therapy to remedy radiation-induced injury and restore impaired new bone formation during distraction osteogenesis (DO). BMSC therapy brought about the successful generation of new bone and significantly improved both the rate and quality of a bony union of irradiated, distracted [X-ray radiation therapy (XRT)/DO] murine mandibles to the level of nonirradiated DO animals. The bone mineral density and bone volume fraction were also significantly improved by the BMSC replacement therapy showing no difference when compared to nonirradiated animals. Finally, a biomechanical analysis examining the yield, failure load, and ultimate load also demonstrated a significantly improved structural integrity in BMSC-treated XRT/DO mandibles over XRT/DO alone. These results indicate that administration of BMSCs intraoperatively to a radiated distraction gap can function as an adequate stimulant to rescue the ability for irradiated bone to undergo DO and produce a healed regenerate of a vastly superior quality and strength. We believe that the fundamental information on the optimization of bone regeneration in the irradiated mandible provided by this work has immense potential to be translated from the bench to the bedside to lead to improved therapeutic options for patients suffering from the disastrous sequelae of radiation therapy.
Sagar S Deshpande; Kathleen K Gallagher; Alexis Donneys; Catherine N Tchanque-Fossuo; Deniz Sarhaddi; Hongli Sun; Paul H Krebsbach; Steven R Buchman
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-02-19
Journal Detail:
Title:  Stem cells and development     Volume:  22     ISSN:  1557-8534     ISO Abbreviation:  Stem Cells Dev.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-20     Completed Date:  2013-12-11     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  101197107     Medline TA:  Stem Cells Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1625-32     Citation Subset:  IM    
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MeSH Terms
Bone Density / radiation effects
Bone Regeneration*
Facial Bones / radiation effects,  surgery
Mandible / radiation effects*,  surgery*
Mesenchymal Stem Cell Transplantation*
Mesenchymal Stromal Cells
Osteogenesis, Distraction
Rats, Inbred Lew
Skull / radiation effects,  surgery
Tissue Engineering
Tissue Scaffolds
Grant Support
R01 CA 125187-01/CA/NCI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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