| Stem cell sources for vascular tissue engineering and regeneration. | |
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MedLine Citation:
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PMID: 22571595 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This review focuses on the stem cell sources with the potential to be used in vascular tissue engineering and to promote vascular regeneration. The first clinical studies using tissue-engineered vascular grafts are already under way, supporting the potential of this technology in the treatment of cardiovascular and other diseases. Despite progress in engineering biomaterials with the appropriate mechanical properties and biological cues as well as bioreactors for generating the correct tissue microenvironment, the source of cells that make up the vascular tissues remains a major challenge for tissue engineers and physicians. Mature cells from the tissue of origin may be difficult to obtain and suffer from limited proliferative capacity, which may further decline as a function of donor age. On the other hand, multipotent and pluripotent stem cells have great potential to provide large numbers of autologous cells with a great differentiation capacity. Here, we discuss the adult multipotent as well as embryonic and induced pluripotent stem cells, their differentiation potential toward vascular lineages, and their use in engineering functional and implantable vascular tissues. We also discuss the associated challenges that need to be addressed in order to facilitate the transition of this technology from the bench to the bedside. |
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Authors:
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Vivek K Bajpai; Stelios T Andreadis |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2012-07-03 |
Journal Detail:
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Title: Tissue engineering. Part B, Reviews Volume: 18 ISSN: 1937-3376 ISO Abbreviation: Tissue Eng Part B Rev Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-09-26 Completed Date: 2013-02-07 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 101466660 Medline TA: Tissue Eng Part B Rev Country: United States |
Other Details:
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Languages: eng Pagination: 405-25 Citation Subset: IM |
Affiliation:
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Bioengineering Laboratory, Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Amherst, New York 14260-4200, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Differentiation Humans Regeneration* Stem Cells / cytology* Tissue Engineering* |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL086582/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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