| Stem cell-based therapies and immunomodulatory approaches in newly diagnosed type 1 diabetes. | |
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MedLine Citation:
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PMID: 20955160 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Type 1 diabetes mellitus is an autoimmune disease against pancreatic β cells. The autoimmune response begins months or years before the clinical presentation. At the time of hyperglycemic symptoms a small amount of β cell mass still remains. The main therapeutic option to type 1 diabetes mellitus is daily insulin injections which is shown to promote tighter glucose control and to reduce much of diabetic chronic complications. Subgroup analysis of the Diabetes Control and Complication Trial (DCCT) showed another important aspect related to long term complications of diabetes, ie, patients with initially larger residual β cell mass suffered less microvascular complications and less hypoglycemic events than those patients with small amounts of β cells at diagnosis. In face of this, β cell preservation has become another important target in the management of type 1 diabetes and its related complications. In this review, we summarize various immunomodulatory regimens ever used in humans, including stem cell-based strategies, aiming at blocking autoimmunity against pancreatic β cells and at promoting β cell preservation and/or possible β cell regeneration in recent-onset type 1 diabetes. |
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Authors:
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Carlos Eduardo Barra Couri; Júlio César Voltarelli |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current stem cell research & therapy Volume: 6 ISSN: 1574-888X ISO Abbreviation: Curr Stem Cell Res Ther Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-11 Completed Date: 2011-05-20 Revised Date: 2012-01-19 |
Medline Journal Info:
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Nlm Unique ID: 101272517 Medline TA: Curr Stem Cell Res Ther Country: United Arab Emirates |
Other Details:
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Languages: eng Pagination: 10-5 Citation Subset: IM |
Affiliation:
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Department of Clinical Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diabetes Mellitus, Type 1 / immunology, pathology, therapy* Humans Immunomodulation* Immunosuppressive Agents / therapeutic use Insulin-Secreting Cells / immunology, physiology Regeneration Stem Cell Transplantation* Stem Cells / immunology |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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