Document Detail

Stellate cell contraction: role, regulation, and potential therapeutic target.
MedLine Citation:
PMID:  18984467     Owner:  NLM     Status:  MEDLINE    
The contraction of hepatic stellate cells has been proposed to mediate fibrosis by regulating sinusoidal blood flow and extracellular matrix remodeling. Abundant data from diverse, yet complementary, experimental methods support a robust model for the regulation of contractile force generation by stellate cells. In this model, soluble factors associated with liver injury, including endothelin 1 and nitric oxide, are transduced primarily through Rho signaling pathways that promote the myosin II-powered generation of contractile force by stellate cells. The enhanced knowledge of the role and differential regulation of stellate cell contraction may facilitate the discovery of new and targeted strategies for the prevention and treatment of hepatic fibrosis.
Russell K Soon; Hal F Yee
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinics in liver disease     Volume:  12     ISSN:  1557-8224     ISO Abbreviation:  Clin Liver Dis     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-05     Completed Date:  2009-03-05     Revised Date:  2013-06-04    
Medline Journal Info:
Nlm Unique ID:  9710002     Medline TA:  Clin Liver Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  791-803, viii     Citation Subset:  IM    
Department of Medicine and Liver Center, University of California, San Francisco, CA 94110, USA.
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MeSH Terms
Contractile Proteins / metabolism
Endothelin-1 / metabolism*
Extracellular Matrix / metabolism
Hepatic Stellate Cells / drug effects,  metabolism,  physiology*
Intracellular Signaling Peptides and Proteins / metabolism
Liver Cirrhosis / metabolism,  physiopathology*,  therapy*
Myosin Type II / metabolism*
Nitric Oxide / metabolism*
Portal System / metabolism
Signal Transduction
rho-Associated Kinases / metabolism
Grant Support
Reg. No./Substance:
0/Contractile Proteins; 0/Endothelin-1; 0/Intracellular Signaling Peptides and Proteins; 10102-43-9/Nitric Oxide; EC Kinases; EC 3.6.1.-/Myosin Type II

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