Document Detail


Stellate cell contraction: role, regulation, and potential therapeutic target.
MedLine Citation:
PMID:  18984467     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The contraction of hepatic stellate cells has been proposed to mediate fibrosis by regulating sinusoidal blood flow and extracellular matrix remodeling. Abundant data from diverse, yet complementary, experimental methods support a robust model for the regulation of contractile force generation by stellate cells. In this model, soluble factors associated with liver injury, including endothelin 1 and nitric oxide, are transduced primarily through Rho signaling pathways that promote the myosin II-powered generation of contractile force by stellate cells. The enhanced knowledge of the role and differential regulation of stellate cell contraction may facilitate the discovery of new and targeted strategies for the prevention and treatment of hepatic fibrosis.
Authors:
Russell K Soon; Hal F Yee
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinics in liver disease     Volume:  12     ISSN:  1557-8224     ISO Abbreviation:  Clin Liver Dis     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-05     Completed Date:  2009-03-05     Revised Date:  2013-06-04    
Medline Journal Info:
Nlm Unique ID:  9710002     Medline TA:  Clin Liver Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  791-803, viii     Citation Subset:  IM    
Affiliation:
Department of Medicine and Liver Center, University of California, San Francisco, CA 94110, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Contractile Proteins / metabolism
Endothelin-1 / metabolism*
Extracellular Matrix / metabolism
Hepatic Stellate Cells / drug effects,  metabolism,  physiology*
Humans
Intracellular Signaling Peptides and Proteins / metabolism
Liver Cirrhosis / metabolism,  physiopathology*,  therapy*
Myosin Type II / metabolism*
Nitric Oxide / metabolism*
Portal System / metabolism
Signal Transduction
rho-Associated Kinases / metabolism
Grant Support
ID/Acronym/Agency:
R01 DK061532-05/DK/NIDDK NIH HHS; R01 DK61532/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Contractile Proteins; 0/Endothelin-1; 0/Intracellular Signaling Peptides and Proteins; 10102-43-9/Nitric Oxide; EC 2.7.11.1/rho-Associated Kinases; EC 3.6.1.-/Myosin Type II
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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