Document Detail

Steatorrhea in patients with intrahepatic cholestasis of pregnancy.
MedLine Citation:
PMID:  3609667     Owner:  NLM     Status:  MEDLINE    
A prospective study was undertaken to evaluate fat malabsorption during intrahepatic cholestasis of pregnancy (ICP), a disease characterized by a mild cholestasis of short duration appearing in otherwise healthy young women. An abnormal fecal fat excretion (mean 15.8 g/24 h, range 6-31 g/24 h) was demonstrated in 10 of 12 patients with the icteric form of ICP and in 2 of 11 patients with pruritus gravidarum. The increased fecal fat excretion was generally asymptomatic, could be detected as early as 3 wk after the clinical onset of ICP, remained stable during the affected pregnancies, and returned to normal from 3 to 9 wk after delivery. Steatorrhea correlated with the severity of ICP, estimated by serum levels of bilirubin, total bile salts, and glutamic pyruvic transaminase. A significant fall in the maternal weight/height index was detected after the onset of ICP, being more intense in patients with steatorrhea than in those without it (to 92.6% +/- 3.0% of initial values versus 96.7% +/- 2.8%, respectively; p less than 0.05). A high risk of premature deliveries and fetal distress was demonstrated in these patients, also correlating with the severity of ICP. No direct relationship could be established between steatorrhea or maternal nutritional impairment and fetal prognosis.
H Reyes; M E Radrigan; M C Gonzalez; R Latorre; J Ribalta; N Segovia; C Alvarez; M Andresen; D Figueroa; B Lorca
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gastroenterology     Volume:  93     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1987 Sep 
Date Detail:
Created Date:  1987-09-09     Completed Date:  1987-09-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  584-90     Citation Subset:  AIM; IM    
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MeSH Terms
Celiac Disease / metabolism*
Cholestasis, Intrahepatic / metabolism*
Fats / analysis
Feces / analysis
Follow-Up Studies
Infant, Newborn
Nutritional Status
Pregnancy Complications / metabolism*
Prospective Studies
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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