Document Detail


Stearoyl-CoA desaturase-2 gene expression is required for lipid synthesis during early skin and liver development.
MedLine Citation:
PMID:  16118274     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There are four known stearoyl-CoA desaturase (SCD) enzyme isoforms in mouse and two in humans that are required for the biosynthesis of monounsaturated fatty acids, mainly oleate. SCD1 isoform plays a role in the regulation of energy metabolism and lipid synthesis, but the roles of the other SCD isoforms have not been investigated. Here we show that the SCD2 isoform is important in lipid synthesis in early development and is required for survival. SCD2-deficient (Scd2-/-) neonatal mice have a skin permeability barrier defect and a specific repartitioning of linoleic acid from epidermal acylceramide species into phospholipids. SCD2 expression is high in liver of wild-type mouse embryos and neonates between embryonic day 18.5 and 21 days of age and is decreased in adult mice. SCD1 expression, on the other hand, is induced after weaning. The liver, skin, and plasma triglyceride contents are decreased in the neonates but are not altered in the adult Scd2-/- mice. These results indicate that, although SCD1 expression is important in adult mice, SCD2 is crucial in the synthesis of monounsaturated fatty acids that are required for maintaining normal epidermal permeability barrier function and biosynthesis of lipids during early skin and liver development.
Authors:
Makoto Miyazaki; Agnieszka Dobrzyn; Peter M Elias; James M Ntambi
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.     Date:  2005-08-23
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  102     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-31     Completed Date:  2005-10-13     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  12501-6     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA. miyazakim@biochem.wisc.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Base Sequence
DNA / genetics
Fatty Acids / metabolism
Female
Gene Expression Regulation, Developmental
Isoenzymes / genetics
Lipids / biosynthesis*
Liver / embryology,  growth & development*,  metabolism*
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Pregnancy
Skin / embryology,  growth & development*,  metabolism*
Stearoyl-CoA Desaturase / genetics*
Triglycerides / metabolism
Grant Support
ID/Acronym/Agency:
R01162388//PHS HHS
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Isoenzymes; 0/Lipids; 0/Triglycerides; 9007-49-2/DNA; EC 1.14.19.1/Stearoyl-CoA Desaturase
Comments/Corrections

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