| Stearidonic Acid Raises Red Blood Cell Membrane Eicosapentaenoic Acid. | |
| | |
MedLine Citation:
|
PMID: 22279138 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The consumption of EPA and DHA has been associated with reduced risk for cardiovascular disease morbidity and mortality. Mean intakes of EPA and DHA in the United States and elsewhere are below levels recommended by health authorities. The main non-marine source of dietary (n-3) fatty acids (α-linolenic acid) is poorly converted to EPA in humans. Stearidonic acid (SDA) is a non-marine fatty acid that appears to be more readily converted to EPA in humans. Results from previous studies suggested that SDA, relative to EPA, increases RBC EPA, with reported efficiencies ranging from ~16 to 30%. A recently published, randomized, single-blind, controlled, parallel group study in healthy men and women characterized the relationships between intakes of SDA and EPA and EPA enrichment of RBC membranes over a 12-wk period. %EPA in RBC membranes was greater after EPA (0.44, 1.3, or 2.7 g/d, respectively) and SDA (1.3, 2.6, or 5.2 g/d, respectively) consumption compared to a safflower control (all P < 0.02). Based on quadratic response surface models, for EPA intakes of 0.25, 0.50, and 0.89 g/d, SDA intakes of 0.61, 1.89, and 5.32 g/d, respectively, would be required to produce equivalent values for RBC %EPA, translating to relative efficiencies of 41.0, 26.5, and 16.7%. Thus, dietary SDA over a range of intakes increases RBC %EPA, with declining relative efficiency as SDA intake increases. |
| | |
Authors:
|
Kevin C Maki; Tia M Rains |
Related Documents
:
|
18039568 - Pulping cardoon (cynara cardunculus) with peroxyformic acid (milox) in one single stage. 18800508 - Np1ec degradation pathways under oxic and microxic conditions. 11386868 - Characterization of dicarboxylic acids for cellulose hydrolysis. 16125828 - Origin of 2-ethylhexanol as a voc. 18038998 - Structure-antifungal activity relationship of cinnamic acid derivatives. 16656318 - Amino acid incorporation by wheat chloroplasts. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-25 |
Journal Detail:
|
Title: The Journal of nutrition Volume: - ISSN: 1541-6100 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-26 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0404243 Medline TA: J Nutr Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Provident Clinical Research, Biofortis North America, Glen Ellyn, IL. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Suppression of Hypoxia-Inducible Factor-1 ? Contributes to the Antiangiogenic Activity of Red Propol...
Next Document: Melissa officinalis Essential Oil Reduces Plasma Triglycerides in Human Apolipoprotein E2 Transgenic...