Document Detail

Stearic acid is well absorbed from short- and long-acyl-chain triacylglycerol in an acute test meal.
MedLine Citation:
PMID:  17299476     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Absorption of stearic acid from natural oils has been shown to be efficient, but it is claimed to be lower from short- and long-acyl-chain triacylyglycerol molecules (Salatrim). The aim was to measure the apparent absorption of stearic acid from Salatrim fat in an acute test meal. DESIGN: Double-blind crossover study. SUBJECTS: Ten healthy male volunteers, of whom eight completed the study. METHODS: The subjects were studied on two occasions after consumption of a single high-fat meal either without (control) or with 30 g of Salatrim. Fecal samples were collected for 96 h after the meal and the fat was extracted for analysis of the content and composition of free and esterified long-chain fatty acids. RESULTS: Baseline fecal fat was 5.6+/-2.6 g/day increasing to 10.4+/-4.9 g/day after addition of Salatrim (P=0.001). During the whole collection period, the baseline fecal free and esterified fatty acids were 2.6+/-2.3 and 0.8+/-0.7 g, respectively. After Salatrim meal the corresponding figures increased to 5.9+/-3.6 g (P=0.001) and 1.5 (+/-1.2) g (P=0.003), respectively. The total fecal stearic acid after control meal was 0.97+/-0.9 g. Consumption of Salatrim with 16.7+/-0.5 g of stearic acid increased the content to 3.12+/-1.6 g (P<0.001), with apparent absorption of 87%. CONCLUSIONS: The apparent absorption of stearic acid does not differ from its absorption from natural fats. The status of Salatrim as a low-energy fat substitute needs to be re-evaluated. SPONSORSHIP: University of Turku.
S Tuomasjukka; M Viitanen; H Kallio
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-02-14
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  61     ISSN:  0954-3007     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-06     Completed Date:  2008-02-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  1352-8     Citation Subset:  IM    
Department of Biochemistry and Food Chemistry, University of Turku, Turku, Finland.
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MeSH Terms
Cross-Over Studies
Diet, Fat-Restricted
Double-Blind Method
Fatty Acids / analysis
Fatty Acids, Nonesterified / analysis
Feces / chemistry*
Intestinal Absorption / drug effects*
Stearic Acids / pharmacokinetics*
Triglycerides / chemistry*,  pharmacokinetics
Reg. No./Substance:
0/Fatty Acids; 0/Fatty Acids, Nonesterified; 0/Stearic Acids; 0/Triglycerides; 57-11-4/stearic acid; 64706-27-0/salatrim

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