Document Detail


Stearate preferentially induces apoptosis in human breast cancer cells.
MedLine Citation:
PMID:  19838949     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Stearic acid (stearate) is an 18-carbon saturated fatty acid that has been shown to inhibit invasion and proliferation and induce apoptosis in various human cell types. The specificity of stearate-induced apoptosis for cancerous versus noncancerous breast cells has not been examined, and the mechanism underlying stearate-induced apoptosis is unknown. Morphological analysis, cell viability, and caspase-3 activity assays demonstrated that stearate activated apoptosis preferentially in cancerous breast cells in a time- and dose-dependent manner. Inhibition of de novo diacylgycerol synthesis or protein kinase C (PKC) blocked stearate-induced caspase-3 activity, indicating the involvement of a novel or classical PKC isozyme. To our knowledge this is the first study showing that stearate induces apoptosis preferentially in breast cancer cells and implicates protein kinase C in the signaling cascade. These results raise the possibility of dietary stearate having a beneficial role in the prevention or treatment of breast cancer.
Authors:
Lynda M Evans; Stephanie L Cowey; Gene P Siegal; Robert W Hardy
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nutrition and cancer     Volume:  61     ISSN:  1532-7914     ISO Abbreviation:  Nutr Cancer     Publication Date:  2009  
Date Detail:
Created Date:  2009-10-19     Completed Date:  2010-01-15     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  7905040     Medline TA:  Nutr Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  746-53     Citation Subset:  IM    
Affiliation:
University of Alabama at Birmingham, Birmingham, Alabama, USA.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / administration & dosage*
Apoptosis*
Breast Neoplasms / metabolism,  pathology*
Caspase 3 / metabolism
Cell Line
Cell Line, Tumor
Cell Movement
Cell Shape
Cell Survival
Coenzyme A Ligases / antagonists & inhibitors
Dietary Fats
Diglycerides / biosynthesis
Female
Humans
Protein Kinase C / antagonists & inhibitors,  metabolism
Stearic Acids / administration & dosage*
Grant Support
ID/Acronym/Agency:
R21 AT 001636/AT/NCCAM NIH HHS; R21 AT 002922/AT/NCCAM NIH HHS; R21 AT001636-02/AT/NCCAM NIH HHS; R21 AT002922-02/AT/NCCAM NIH HHS
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Dietary Fats; 0/Diglycerides; 0/Stearic Acids; EC 2.7.11.13/Protein Kinase C; EC 3.4.22.-/Caspase 3; EC 6.2.1.-/Coenzyme A Ligases
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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