| Stearate preferentially induces apoptosis in human breast cancer cells. | |
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MedLine Citation:
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PMID: 19838949 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Stearic acid (stearate) is an 18-carbon saturated fatty acid that has been shown to inhibit invasion and proliferation and induce apoptosis in various human cell types. The specificity of stearate-induced apoptosis for cancerous versus noncancerous breast cells has not been examined, and the mechanism underlying stearate-induced apoptosis is unknown. Morphological analysis, cell viability, and caspase-3 activity assays demonstrated that stearate activated apoptosis preferentially in cancerous breast cells in a time- and dose-dependent manner. Inhibition of de novo diacylgycerol synthesis or protein kinase C (PKC) blocked stearate-induced caspase-3 activity, indicating the involvement of a novel or classical PKC isozyme. To our knowledge this is the first study showing that stearate induces apoptosis preferentially in breast cancer cells and implicates protein kinase C in the signaling cascade. These results raise the possibility of dietary stearate having a beneficial role in the prevention or treatment of breast cancer. |
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Authors:
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Lynda M Evans; Stephanie L Cowey; Gene P Siegal; Robert W Hardy |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nutrition and cancer Volume: 61 ISSN: 1532-7914 ISO Abbreviation: Nutr Cancer Publication Date: 2009 |
Date Detail:
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Created Date: 2009-10-19 Completed Date: 2010-01-15 Revised Date: 2013-05-31 |
Medline Journal Info:
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Nlm Unique ID: 7905040 Medline TA: Nutr Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 746-53 Citation Subset: IM |
Affiliation:
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University of Alabama at Birmingham, Birmingham, Alabama, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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administration & dosage* Apoptosis* Breast Neoplasms / metabolism, pathology* Caspase 3 / metabolism Cell Line Cell Line, Tumor Cell Movement Cell Shape Cell Survival Coenzyme A Ligases / antagonists & inhibitors Dietary Fats Diglycerides / biosynthesis Female Humans Protein Kinase C / antagonists & inhibitors, metabolism Stearic Acids / administration & dosage* |
| Grant Support | |
ID/Acronym/Agency:
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R21 AT 001636/AT/NCCAM NIH HHS; R21 AT 002922/AT/NCCAM NIH HHS; R21 AT001636-02/AT/NCCAM NIH HHS; R21 AT002922-02/AT/NCCAM NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Dietary Fats; 0/Diglycerides; 0/Stearic Acids; EC 2.7.11.13/Protein Kinase C; EC 3.4.22.-/Caspase 3; EC 6.2.1.-/Coenzyme A Ligases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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