Document Detail


Steady state verapamil tissue distribution in the dog: differing tissue accumulation.
MedLine Citation:
PMID:  3725887     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plasma, heart, and extracardiac tissue verapamil concentrations were measured after sustained intravenous infusions in 11 dogs to determine the differential tissue accumulation of verapamil. A steady state verapamil concentration of 327 +/- 50 ng/ml decreased the mean arterial blood pressure from 104 +/- 9 to 90 +/- 6 mm Hg (p = 0.08) and the P-R interval increased from 118 +/- 4 to 176 +/- 13 ms (p less than 0.001) with second-degree atrioventricular block developing in 6 animals. Verapamil accumulated in organs in the following order: Lung much greater than kidney greater than spleen greater than ventricular myocardium = liver greater than atrial myocardium greater than cerebral cortex greater than fat = skeletal muscle. Levels in the ventricular free wall were consistently greater than atrial levels, but no difference was observed between left versus right-sided cardiac chambers. In summary, affinity of different organs for verapamil is highly variable and organ-specific; furthermore, differential intracardiac chamber accumulation occurs.
Authors:
J B Schwartz; E Todd; D R Abernethy; J R Mitchell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pharmacology     Volume:  32     ISSN:  0031-7012     ISO Abbreviation:  Pharmacology     Publication Date:  1986  
Date Detail:
Created Date:  1986-08-06     Completed Date:  1986-08-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0152016     Medline TA:  Pharmacology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  307-12     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Dogs
Electrocardiography
Male
Myocardium / metabolism*
Tissue Distribution
Verapamil / analogs & derivatives,  blood,  metabolism*,  pharmacology
Grant Support
ID/Acronym/Agency:
RR-00350/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
52-53-9/Verapamil; 67018-85-3/norverapamil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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